Peptide and Compound Library
One reference page per compound. Each states what the molecule is, shows a structure only where a verified one exists and says where it came from, and separates what experiments established from what is still open. Blends are described by their components; a mixture has no single structure.
Every entry is written from primary literature and public databases and checked by automated review. How this library is built
Showing 23 of 23 entries
Incretin and amylin receptor agonists (1)
Peptides engineered to act at the GLP-1, GIP, glucagon or amylin receptors, most of them lipidated to extend their time in circulation.
GHRH analogues and ghrelin-receptor agonists (5)
Analogues of growth-hormone-releasing hormone, and synthetic peptides that act at the ghrelin receptor (GHS-R1a).
- CJC-1295 with DACCJC-1295 with DAC is a 30-residue analogue of the first 29 residues of human growth hormone-releasing hormone, carrying four changes and an added lysine. That C-terminal lysine's side chain bears a maleimide, which reacts with a free protein thiol, so the peptide ends up covalently attached to a plasma protein rather than circulating alone; DAC, drug affinity complex, is the name for that arm.PeptideNo 3D model
- CJC-1295 without DACCJC-1295 without DAC is a 29-residue analogue of the amino-terminal fragment of human growth hormone-releasing hormone, ending in an argininamide. It carries four changes to that sequence (a D-alanine at position 2, glutamine at 8, alanine at 15 and leucine at 27) and none of the carrier-binding chemistry that the suffix DAC names.PeptideNo 3D model
- IpamorelinIpamorelin is a synthetic pentapeptide amide that activates the growth hormone secretagogue receptor, reported in 1998. It is known for not raising corticotropin or cortisol in the species tested.PeptideNo 3D model
- SermorelinSermorelin is a synthetic 29-residue fragment of growth hormone-releasing hormone, the hypothalamic peptide that signals the pituitary, ending in an arginine amide.PeptideExperimental, in a complex
- TesamorelinTesamorelin is the full 44-residue human growth hormone-releasing hormone sequence, C-terminally amidated as the natural hormone is. It carries one added group: a trans-3-hexenoyl acyl chain on the amine of the N-terminal tyrosine.PeptideExperimental, in a complex
Growth hormone, IGF-1 and derived fragments (2)
The growth hormone and IGF-1 proteins, engineered variants of them, and short peptides cut from their sequences.
- AOD-9604AOD-9604, also catalogued as LAT-8881, is a synthetic 16-residue peptide closed by one disulfide. It is the last fifteen residues of human growth hormone with a tyrosine added at the amino terminus that the hormone does not have. It was taken through phase 2 trials for obesity in the 2000s, was never approved, and is prohibited in sport.PeptideExperimental, in a complex
- IGF-1 LR3IGF-1 LR3 is an engineered 83-residue analogue of human insulin-like growth factor I that binds the IGF binding proteins poorly. Its only established use is as a reagent in serum-free cell culture.Protein or biologicExperimental structure
Melanocortin peptides and alpha-MSH fragments (2)
Analogues of alpha-melanocyte-stimulating hormone that act at melanocortin receptors, and a tripeptide cut from its C-terminus.
- KPVKPV is a three-amino-acid fragment from the end of alpha-melanocyte-stimulating hormone: the tripeptide Lys-Pro-Val, positions 11 to 13. That thirteen-residue hormone's His-Phe-Arg-Trp sequence, which melanocortin receptors recognise, is absent from it.PeptideCalculated conformer
- PT-141 (bremelanotide)PT-141 is the development code for bremelanotide, a synthetic cyclic heptapeptide melanocortin receptor agonist approved in the United States in 2019. It differs from melanotan II by a single functional group at the C terminus.PeptideExperimental, in a complex
Copper peptides (1)
Short peptides catalogued as copper(II) complexes, with the metal held by the N-terminal amine and a histidine.
Thymosins (2)
Thymosin alpha-1 and a short acetylated fragment of thymosin beta-4.
- TB-500TB-500 is the name used for Ac-LKKTETQ, a seven-residue acetylated peptide, and it is not the protein thymosin beta-4. The sequence matches residues 17 to 23 of that 43-residue protein.PeptideNo 3D modelidentity partially verified
- Thymosin alpha-1Thymosin alpha-1 is a 28-residue acidic peptide, acetylated on its first serine, cut out of the larger human protein prothymosin alpha. It was first isolated from a calf thymus extract in the mid-1970s.PeptideExperimental structure
Khavinson short peptides and tissue extracts (1)
Di-, tri- and tetrapeptides and tissue extracts from the St Petersburg bioregulator programme associated with V. Kh. Khavinson.
Mitochondria-encoded and mitochondria-targeted peptides (2)
Peptides encoded in the mitochondrial genome, and a synthetic tetrapeptide designed to accumulate at the inner mitochondrial membrane.
- MOTS-cMOTS-c is a 16-residue peptide, MRWQEMGYIFYPRKLR, encoded by a 51 base pair reading frame inside the human mitochondrial 12S ribosomal RNA gene. It has no identified receptor, no published affinity constant and no deposited three-dimensional structure.PeptideNo 3D model
- SS-31 (elamipretide)SS-31 (elamipretide) is a synthetic tetrapeptide, D-Arg-Dmt-Lys-Phe-NH2, built from alternating cationic and aromatic residues. It is studied for its selective binding to cardiolipin, the anionic phospholipid of the inner mitochondrial membrane.PeptideNo 3D model
Neuropeptides, their analogues and brain-derived preparations (3)
Endogenous neuropeptides, synthetic analogues and fragments of them, and a porcine brain protein hydrolysate.
- DSIP (delta sleep-inducing peptide)DSIP is a nine-residue peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, recovered in 1977 from rabbit cerebral venous blood and named for an EEG change. No receptor for it has ever been found.PeptideNo 3D model
- SelankSelank is a synthetic tuftsin analogue from the Russian regulatory-peptide programme, a heptapeptide with no identified molecular target. It has been studied mainly in rodent anxiety-related behaviour, transcript arrays and enzyme assays.PeptideNo 3D model
- SemaxSemax is a synthetic corticotropin-fragment peptide designed in Moscow in the 1980s and in Russian medical use since. It is made by joining residues 4 to 7 of adrenocorticotropic hormone to a Pro-Gly-Pro tail.PeptideNo 3D model
Other synthetic peptides and engineered proteins (1)
Peptides and proteins that share no receptor family with the classes above, each described on its own terms.
Coenzymes, redox molecules and synthetic small molecules (3)
Nicotinamide nucleotides, glutathione and its precursor, and two synthetic small molecules made as enzyme or receptor tools.
- Glutathione (reduced, GSH)Glutathione is the cysteine-containing tripeptide that cells build for themselves, and the most abundant low-molecular-weight thiol in animal cells. It exists as a reduced form carrying a free thiol, written GSH, and as its disulfide dimer GSSG, and almost all of its chemistry runs through that one sulfur.PeptideExperimental, in a complex
- Nicotinamide adenine dinucleotide (NAD+)NAD+ is the oxidised form of nicotinamide adenine dinucleotide, in which nicotinamide riboside and adenosine are joined through a pyrophosphate bridge. Cells use it both as a carrier of hydride in redox reactions and as a substrate that sirtuins, PARPs, CD38 and SARM1 cleave.Small moleculeExperimental, in a complex
- SLU-PP-332SLU-PP-332 is a synthetic small-molecule research probe that raises the transcriptional activity of all three estrogen-related receptors, ERR alpha, beta and gamma. It was designed at Saint Louis University in 2023 and reported with its highest potency at the alpha paralog.Small moleculeCalculated conformer
