Key Takeaways
- •Independent third-party certificate of analysis publicly available.
- •At least 99% purity by HPLC, the standard for research peptides.
- •Mass spectrometry confirming identity, matching about 2174 Da molecular weight.
- •Production via solid-phase peptide synthesis (SPPS) using synthetic amino acids, free of animal materials.
- •Domestic Canadian supply to avoid customs and currency issues.
Distinct Origin of MOTS-c
MOTS-c differs from most research peptides due to its source in mitochondrial DNA, specifically the 12S rRNA gene. This 16-amino-acid sequence belongs to mitochondrial-derived peptides (MDPs), a category that includes humanin. Canadian researchers studying mitochondrial biology or longevity find value in its established data on metabolic and aging processes.
Its discovery dates to 2015 by Lee and colleagues, marking it as a recent addition to peptide studies. Unlike peptides from nuclear DNA, MOTS-c arises naturally in human cells during mitochondrial function. Check the Peptide Glossary for more on MDPs.
Core Research Mechanisms
Studies since 2015 highlight MOTS-c's roles in mitochondrial function and metabolic control. It activates the AMPK signaling pathway, improves insulin sensitivity, and affects glucose homeostasis. Research also shows effects on cellular energy use and aging-related metabolic shifts.
A 2018 study by Kim et al. revealed MOTS-c translocates from mitochondria to the nucleus, altering gene expression under metabolic stress. This sets it apart from peptides acting on receptors, angiogenic paths, or copper pathways. It targets mitochondrial biology directly.
Value of Mitochondrial DNA Source
Nearly all research peptides, such as those like GHRH analogs or metabolic types, come from nuclear DNA. MOTS-c's mitochondrial encoding ties it to energy production systems key to aging and metabolism studies. Mitochondrial issues rank among the hallmarks of aging per López-Otín et al. in 2013.
The MDP field grows as more peptides emerge alongside humanin. For Canadian work, MOTS-c fills a niche in mitochondrial research untouched by other peptides. Its unique background supports investigations into dysfunction central to aging.
Essential Checks for MOTS-c Purchases
Use this six-point list for research-grade MOTS-c:
- Independent third-party certificate of analysis publicly available.
- At least 99% purity by HPLC, the standard for research peptides.
- Mass spectrometry confirming identity, matching about 2174 Da molecular weight.
- Production via solid-phase peptide synthesis (SPPS) using synthetic amino acids, free of animal materials.
- Domestic Canadian supply to avoid customs and currency issues.
- Clear research-use-only labeling from the supplier.
These steps ensure quality for 10mg vials. Browse our catalog for options.
Handling and Storage Protocols
Reconstitute MOTS-c with bacteriostatic water. Tools like the Reconstitution Calculator help with precise calculations.
Store lyophilized vials at 2-8°C for short term or -20°C for longer periods. Keep reconstituted solutions refrigerated and use within about 28 days.
Benefits of Canadian Sourcing
MOTS-c availability from Canadian suppliers lags behind compounds like certain healing or copper peptides. International sources bring risks of customs delays, extra costs in currency conversion, and extended shipping times of weeks.
Domestic options provide same-day shipping from areas like Ontario, 2-5 business day delivery nationwide, and pricing in Canadian dollars. This setup offers verifiable quality without border hurdles.
Key Research Uses
MOTS-c suits studies on:
- Mitochondrial dysfunction.
- Metabolic regulation via AMPK and insulin paths.
- Aging-linked metabolic changes.
- Longevity frameworks, distinct from other peptides' actions.
Its mitochondrial focus aligns directly with core aging mechanisms. Researchers gain a targeted tool for energy and metabolic inquiries.
In summary, MOTS-c's mitochondrial roots and validated mechanisms make it essential for specific Canadian research. Prioritize verified quality and domestic access for reliable studies.
Related Research Compounds
Looking for high-purity research peptides? Browse our catalog for HPLC-verified compounds.
| Compound | Purity | Size | Price |
|---|---|---|---|
| MOTS-C 20mg | ≥98% | 20mg | $54.00 |