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Anti-Aging Peptides: Epithalon, NAD+, GHK-Cu Research

Research on anti-aging peptides targets cellular aging processes like telomere shortening, mitochondrial decline, and gene expression changes. Compounds such as Epithalon from Khavinson’s group, GHK-Cu with over 4,000 gene interactions documented by Pickart, and NAD+ for sirtuin activation show promise in preclinical models. These peptides support studies on telomerase activation, collagen synthesis, DNA repair, and more, with all compounds verified at >99% purity by HPLC and published COAs.

Marcus Hopkin, PhD, Director of Research and Development at Volta Peptides.

Reviewed by Marcus Hopkin, PhD

Director of Research and Development, Volta Peptides

Written by Volta Peptides Editorial Team · Reviewed September 15, 2026

May 12, 2026Updated June 19, 20263 min read
Anti-Aging Peptides: Epithalon, NAD+, GHK-Cu Research

Key Takeaways

  • •Researchers have identified key cellular changes in aging, including telomere shortening, mitochondrial decline, and shifts in gene expression.
  • •GHK-Cu Copper Peptide 50mg supports research on skin and cellular repair.
  • •Khavinson’s group produced some of the most cited studies on Epithalon.

Pickart Documents Over 4,000 Gene Interactions for GHK-Cu

Researchers have identified key cellular changes in aging, including telomere shortening, mitochondrial decline, and shifts in gene expression. Pickart’s early work on copper peptides like GHK-Cu revealed broad transcriptional effects across aging pathways. This compound has been studied for collagen synthesis and antioxidant gene upregulation, with documentation of over 4,000 gene interactions.

GHK-Cu Copper Peptide 50mg supports research on skin and cellular repair. Its effects span multiple pathways relevant to aging.

Epithalon and Telomere Research from Khavinson’s Group

Khavinson’s group produced some of the most cited studies on Epithalon. This tetrapeptide has been examined in preclinical models for telomerase activation, circadian rhythm regulation, and longevity-related gene expression.

Epithalon 20mg aids investigations into telomere lengthening and anti-aging effects. These findings position it at the intersection of core aging mechanisms.

For detailed protocols, consult the Peptide Glossary or use the Reconstitution Calculator.

NAD+ Role in Cellular Energy and DNA Repair

NAD+ 750mg has been tested in models of cellular aging for sirtuin activation and PARP-mediated DNA repair. As one of the most studied coenzymes in longevity research, it influences energy production and repair processes.

Studies highlight its potential in maintaining cellular function during aging. This compound overlaps with pathways for neuroprotection and hormone regulation.

MOTS-c and Mitochondrial Function

MOTS-c, a mitochondrial-derived peptide, has been researched for AMPK activation and mitochondrial biogenesis in metabolic and aging models. It targets energy metabolism at the cellular level.

These investigations connect mitochondrial health to broader anti-aging effects. Researchers use it to probe biogenesis pathways.

In Stock

GHK-Cu 50mg

Batch purity 99.8%· 100mg lot
$39 USD
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GHK-Cu 100mg

Batch purity 99.8%
$59 USD
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Epithalon 10mg

$34 USD

Immune and Repair Peptides in Aging Studies

Thymosin Alpha-1 has been investigated in immune aging research for T-cell maturation, dendritic cell signaling, and toll-like receptor modulation.

TB-500 Thymosin Beta-4 supports recovery and repair research. BPC-157 5mg focuses on tissue repair and gut health studies. Both contribute to cellular health explorations.

Check the BPC-157 Research Guide and TB-500 Research Guide for more on these compounds.

Research Stacks for Overlapping Pathways

One stack combines NAD+, Semax, and CJC-1295 to examine cellular energy production, neuroprotection, and growth hormone secretion in a single protocol. Another pairs CJC and Tesamorelin for growth hormone research. Metabolic stacks target fat loss and AMPK pathways.

These combinations allow probing of interconnected aging mechanisms. All compounds are >99% HPLC verified with published COA documentation.

Key Takeaways on Anti-Aging Peptide Research

Anti-aging research centers on peptides like Epithalon, GHK-Cu, and NAD+ that address telomere, mitochondrial, and gene expression issues. Preclinical models show effects on telomerase, collagen, sirtuins, and repair. Use tools like the Dosage & Cycle Planner for precise study designs.


Looking for high-purity research peptides? Browse our catalog for HPLC-verified compounds.

CompoundPuritySizePrice
TB-500 5mg>99%5mg$29.00
BPC-157 5mg>99%5mg$34.00
CJC-1295 No DAC + Ipamorelin 10mg (5+5)>99%10mg$49.00
GHK-Cu 50mg>99%50mg$24.00

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Research Use Only. This article is provided for informational and educational purposes only. The compounds and topics discussed are intended solely for laboratory and scientific research. This content does not constitute medical advice, and Volta Peptides does not endorse or promote human consumption of any research compound.

About the reviewer

Marcus Hopkin, PhD, Director of Research and Development at Volta Peptides.

Marcus Hopkin, PhD

Director of Research and Development, Volta Peptides

Marcus Hopkin, PhD, is Director of Research and Development at Volta Peptides. He has more than 12 years of analytical chemistry experience, including direct laboratory work in peptide synthesis, characterization, purity testing and stability assessment. His doctoral research at the University of Michigan examined novel peptide structures in the human proteome and their potential significance for therapeutic-peptide research. Before joining Volta Peptides he held research and development roles at Amgen and Eli Lilly and Company, and served as a lecturer at the University of Michigan.

Marcus reviewed this article for scientific and analytical accuracy on September 15, 2026. He did not write it. Technical review is internal review and is not peer review, independent third-party review or medical review.

Disclosure. Marcus Hopkin is an employee of Volta Peptides and serves as its Director of Research and Development. Volta Peptides sells research compounds related to subjects discussed in the content he writes and reviews. His reviews are internal scientific and technical review and must not be described as independent third-party review, peer review or medical review.

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Batch purity 99.8%· 100mg lot
$39 USD
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Batch purity 99.8%
$59 USD
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$34 USD
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SS-31 10mg

10mg

Batch purity 99.6%
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Compounds in this article

Supplied for laboratory research use only.

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