PE 22-28 10mg Peptide

TREK-1 knockout animals show a depression-resistant phenotype, which made the channel an attractive target and led to the identification of spadin as an endogenous blocker. PE 22-28 is the minimal active fragment of that peptide, retaining channel-blocking activity at a fraction of the length. What makes it interesting mechanistically is the reported speed of onset in animal models, on the order of days rather than the weeks associated with monoaminergic antidepressants, which points to a distinct pathway. Independent replication outside the originating groups remains limited.