FOXO4-DRI 10mg Peptide

Senescent cells resist apoptosis in part by sequestering p53 in the nucleus through FOXO4 binding. FOXO4-DRI competes for that interaction, releasing p53 to trigger apoptosis selectively in cells where the mechanism is active. The retro-inverso design, a reversed sequence built from D-amino acids, is what gives the peptide protease resistance while preserving the side-chain topology needed for binding. The original 2017 Cell paper by Baar and colleagues is the reference work. It is one of the more expensive research peptides because D-amino-acid synthesis at this length is demanding.