How many peptides are studied for cardiovascular biology?

There are currently 2 peptides with research relevant to cardiovascular biology, ranging from FDA-approved compounds to early-stage research molecules.

Which peptide has the strongest evidence for cardiovascular biology?

Endothelin-1 currently has the strongest evidence rating (B — Well-Characterized / ERA Drugs Approved).

Are these peptides FDA-approved?

Regulatory status varies. Some compounds like certain molecules have FDA approval for specific indications, while others remain in clinical trials or preclinical research.

peptides for usecase

Peptides for Cardiovascular Biology

Comprehensive guide to 2 peptides researched for cardiovascular biology, ranked by evidence strength from FDA-approved to early preclinical. Each compound is evaluated on mechanism, clinical status, and safety profile.

Overview

2 research peptides are currently studied for cardiovascular biology. This guide ranks them by evidence strength and covers their mechanisms, safety profiles, and current clinical status.

Endothelin-1 — Well-Characterized / ERA Drugs Approved

Evidence Rating: B Category: Cardiovascular / Vasoactive

Endothelin-1 (ET-1) is a 21-amino-acid peptide (MW ~2491.9 g/mol) produced primarily by vascular endothelial cells. It is the most potent endogenous vasoconstrictor known, with effects lasting hours. While ET-1 itself is not used therapeutically, endothelin receptor antagonists (ERAs) such as bosent...

Key claims: ET-1 is the most potent endogenous vasoconstrictor; ET-1 pathway is central to pulmonary arterial hypertension pathogenesis.

Angiotensin 1-7 — Preclinical / Early Research

Evidence Rating: D Category: Cardiovascular / Vasoactive

Angiotensin 1-7 is an endogenous 7-amino-acid peptide (sequence: Asp-Arg-Val-Tyr-Ile-His-Pro, MW ~899.0 g/mol) formed primarily by ACE2-mediated cleavage of angiotensin II. It acts as a counter-regulatory arm of the renin-angiotensin system, opposing the vasoconstrictive and pro-inflammatory actions...

Key claims: Produces vasodilation and lowers blood pressure; Cardioprotective in animal models of heart failure.

Related Research News

Regulatory

Aclerastide: Effective Therapy for Diabetic Foot Ulcers

Aclerastide, an analog of angiotensin 1-7, shows strong potential in treating diabetic foot ulcers through progenitor proliferation, vascularization, collagen deposition, and re-epithelialization. Preclinical studies demonstrate its superiority over existing topical growth factors, with Phase II trials confirming faster wound closure lasting up to 20 weeks. Phase III trials are now recruiting patients.

May 12, 2026

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Angiotensin 1-7 Dosing Guide Peptides for Research Peptides for Cardiovascular Biology Endothelin-1 Dosing Guide Peptides for Reference Peptides for Pulmonary Hypertension Research

Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.