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Understand every section of a Certificate of Analysis. Learn what each test measures, what good results look like, and what red flags to watch for.
High-Performance Liquid Chromatography (HPLC) separates the peptide from impurities and measures the percentage of the desired peptide in the sample. It is the single most important quality indicator on a COA.
Purity of 98% or higher is considered research-grade quality. Pharmaceutical-grade peptides typically exceed 99%. Anything above 95% is generally acceptable for research purposes.
Every legitimate COA should have a unique batch or lot number that matches the label on your vial. Contact the vendor if they do not match.
The most trustworthy COAs come from independent, accredited third-party laboratories rather than in-house testing. Look for the lab name, address, and accreditation number.
Search for the testing laboratory online. Legitimate labs have websites, physical addresses, and verifiable accreditations (ISO 17025, GMP, etc.).
A genuine COA should include or be able to provide the actual HPLC chromatogram (the graph showing peaks), not just a purity number. Reluctance to provide this is a red flag.
Some vendors allow you to enter a batch number on their website to pull up the corresponding COA. This helps verify the document was not fabricated.
Professional COAs have consistent formatting, proper letterhead, test dates, analyst signatures or identifiers, and look like professional laboratory documents rather than simple text documents.
Why COAs matter
A Certificate of Analysis is the primary document verifying the identity, purity, and quality of a peptide product. Without a valid COA from a reputable laboratory, there is no way to confirm what is actually in a vial. Always request and review the COA before purchasing from any vendor.