What makes SS-31 different from regular antioxidants?

SS-31 concentrates directly in mitochondria (>1000x enrichment) and prevents ROS formation at the electron transport chain, rather than scavenging free radicals after they form. This targets the source of oxidative stress, making it far more efficient than oral antioxidants like vitamin C or E.

Is SS-31 FDA-approved?

Yes, as of September 2025. SS-31 (Elamipretide) was granted accelerated approval under the brand name Forzinity for Barth syndrome, making it the first FDA-approved mitochondria-targeted therapeutic. It remains investigational for other indications including heart failure and age-related macular degeneration.

What is SS-31 (ELAMIPRETIDE)?

SS-31 (Elamipretide) is a mitochondria-targeted peptide researched for its ability to improve cellular energy production and protect against oxidative stress.

peptide dosing

SS-31 Dosing & Reconstitution Guide

Q: What is the recommended dose range for SS-31?

The research dose range is 5–40 mg/day SC (Phase I tested 0.01–0.25 mg/kg); research protocols typically 10–50 mg, administered via Subcutaneous, Once daily.

Complete dosing reference for SS-31 (Metabolic / Mitochondrial). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Subcutaneous Frequency: Once daily Dose Range: 5–40 mg/day SC (Phase I tested 0.01–0.25 mg/kg); research protocols typically 10–50 mg Cycle Length: 4–12 weeks; clinical trials ran 12–28 weeks Timing: Any consistent time

Reconstitution

Vial Size: 30mg Water Volume: 3mL Concentration: 10mg/mL

Titration Schedule

Week 1: 10 mg daily Weeks 2+: 20–40 mg daily

Storage

Lyophilized: −20 °C (−4 °F) Reconstituted: 2–8 °C (35.6–46.4 °F) Shelf Life: 28 days

Injection Sites

Abdomen, Thigh

Safety & Contraindications

Safety: Generally well-tolerated in clinical trials at tested doses Common: injection site reactions (pain, redness) Mild headache, dizziness, and nausea reported

Contraindications: Pregnancy and breastfeeding (insufficient data); Severe renal impairment (limited pharmacokinetic data); Hypersensitivity to any component

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Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.