TB-500 Dosing & Reconstitution Guide
Dosing Protocol
Route: Subcutaneous Frequency: Once daily Dose Range: 500–1000 mcg/day SC (~5 mg/week average) Cycle Length: 8–12 weeks; optional extension to 16 weeks Timing: Any consistent time daily; rotate injection sites systematically
Reconstitution
Vial Size: 5mg Water Volume: 3mL Concentration: 1.67mg/mL
Titration Schedule
Weeks 1–2: 500 mcg (30 units) Weeks 3–4: 600 mcg (36 units) Weeks 5–8: 750 mcg (45 units) Weeks 9–12: 1000 mcg (60 units)
Timeline & Pharmacokinetics
Onset: 30–60 minutes (subcutaneous) Peak Plasma: 2–4 hours Half-Life: <2 hours plasma; tissue effects persist 2–3 days Steady State: 2–3 weeks with loading protocol Time to Results: 2–4 weeks for inflammation reduction; 4–8 weeks for tissue repair Washout: 2–3 weeks
Storage
Lyophilized: −20 °C (−4 °F), dry, dark conditions Reconstituted: 2–8 °C (35.6–46.4 °F); do not freeze reconstituted solution Shelf Life: 28 days
Injection Sites
Abdomen, Thighs, Upper arms
Safety & Contraindications
Safety: A safety-focused RCT in 40 healthy adults (2010) was designed expressly to assess safety and found minimal adverse effects with synthetic thymosin-beta 4 No significant safety concerns in published human studies to date; TB-500 administration has produced minimal side effects in animal and human studies alike Common anecdotal side effects: injection site pain/redness, lightheadedness, mild headache, nausea, fatigue
Contraindications: Active cancer or history of cancer (research shows contrasting results — TB-500 may slow colon cancer growth by decreasing survival signal activity, but may have negative effects in other cancers); Autoimmune disorders; Pregnancy and breastfeeding
Related Products
Related Research News
TB-500: Thymosin Beta-4's Role in Healing and Repair
TB-500, known as thymosin β4, is a 43-amino-acid peptide first isolated from calf thymus in 1966 by Goldstein et al. It regulates actin in the body, supporting processes like wound healing, angiogenesis, and inflammation control. Research highlights its potential in treating conditions such as myocardial infarction, corneal injuries, and lung damage.
BPC-157 + TB-500 Peptide Blend: Research on Healing and Repair
The BPC-157 and TB-500 peptide blend draws attention in research for potential synergy in tissue repair, angiogenesis, and reducing inflammation. BPC-157, a 15-amino-acid synthetic peptide, interacts with growth factors in preclinical models. TB-500, a 43-amino-acid analog of Thymosin Beta-4, supports cell migration and regeneration. Studies explore their roles in wound healing, tendon recovery, and more.
BPC-157 and TB-500: Synergy in Tissue Repair Research
Researchers frequently examine BPC-157 and TB-500 together due to their potential complementary effects on tissue repair and recovery. BPC-157 supports blood vessel formation and gut integrity, while TB-500 aids cell migration and reduces inflammation. This combination targets multiple healing stages, though evidence remains mostly from preclinical studies.