Peptides for Injury Recovery
Overview
6 research peptides are currently studied for injury recovery. This guide ranks them by evidence strength and covers their mechanisms, safety profiles, and current clinical status.
BPC-157 — Phase I–II Clinical Trials
Evidence Rating: C Category: Healing & Recovery
BPC-157 is a synthetic 15-amino-acid peptide (sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, MW ~1419.5 g/mol) derived from a protein found in human gastric juice. It has demonstrated robust regenerative and cytoprotective effects across hundreds of animal studies spanning te...
Key claims: Accelerates tendon and ligament healing; Heals gut lining and treats leaky gut.
ARA-290 (Cibinetide) — Phase I–II Clinical Trials
Evidence Rating: C Category: Tissue Repair / Neuropathic Pain
ARA-290 (cibinetide) is a synthetic 11-amino-acid peptide (MW ~1257 g/mol) derived from the helix B surface of erythropoietin (EPO). Unlike recombinant EPO, ARA-290 does not bind the classical EPO receptor homodimer and therefore does not stimulate erythropoiesis (red blood cell production), avoidin...
Key claims: Reduces neuropathic pain in sarcoidosis; Promotes corneal nerve fiber regeneration.
TB-500 — Preclinical
Evidence Rating: D Category: Healing & Recovery
TB-500 is a synthetic fragment of thymosin beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide found throughout human tissues. TB-500 contains the active healing region (sequence: Ac-LKKTETQ, MW ~889 g/mol) responsible for cell migration and tissue repair. It has a handful of human RCTs for wo...
Key claims: Accelerates wound healing; Reduces inflammation.
IGF-1 LR3 — Preclinical
Evidence Rating: D Category: Growth Factor
IGF-1 LR3 is a modified version of insulin-like growth factor 1 (IGF-1) with an extended N-terminal sequence (13 additional amino acids) and an arginine-to-glutamic acid substitution at position 3. These modifications dramatically reduce binding to IGF-binding proteins (IGFBPs), resulting in a half-...
Key claims: Promotes muscle growth and hyperplasia; Enhanced recovery from injury.
PEG-MGF — Preclinical
Evidence Rating: D Category: Muscle & Performance
PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of the C-terminal peptide of mechano growth factor (MGF), a splice variant of the IGF-1 gene (IGF-1Ec in humans, IGF-1Eb in rodents). Native MGF is expressed locally in skeletal muscle immediately following mechanical overload ...
Key claims: Activates muscle satellite cells for repair; Promotes muscle hypertrophy.
TB-500 Fragment 17-23 — Preclinical Only
Evidence Rating: D Category: Healing / Research
TB-500 Fragment 17-23 (sequence: LKKTETQ) represents the minimal actin-binding domain of Thymosin Beta-4. This 7-amino-acid fragment retains the ability to sequester G-actin and promote cell migration and wound healing.
Key claims: Concentrated healing activity.
Related Products
Related Research News
BPC-157 Gut Health: Gastric Cytoprotection Studies
Research on BPC-157 began with gastric cytoprotection in the early 1990s, led by Sikiric and colleagues at the University of Zagreb. Studies show it protects against ethanol-induced lesions and NSAID damage in rat models, with effects linked to angiogenesis, prostaglandins, nitric oxide, and gut-brain signaling. This body of work highlights its stability for oral use and broad preclinical applications in GI models.
TB-500: Thymosin Beta-4's Role in Healing and Repair
TB-500, known as thymosin β4, is a 43-amino-acid peptide first isolated from calf thymus in 1966 by Goldstein et al. It regulates actin in the body, supporting processes like wound healing, angiogenesis, and inflammation control. Research highlights its potential in treating conditions such as myocardial infarction, corneal injuries, and lung damage.
BPC-157 Shelf Life: Lyophilized vs Reconstituted Stability Guide
BPC-157 has a finite shelf life that varies by form and storage. Lyophilized powder lasts 12-18 months refrigerated or 24+ months frozen, while reconstituted solution holds for about 28 days under refrigeration. Factors like temperature, light, and handling influence stability, and researchers should watch for signs of degradation to ensure reliable results.