Selank + Semax 20mg Peptide
For in-vitro laboratory research only. Not for human or animal administration.
Batch #: VPSN20100
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Research Use Only
For in-vitro laboratory research by qualified professionals only. Not for human or animal administration. Not a drug, food, cosmetic or dietary supplement. Not intended to diagnose, treat, cure, mitigate or prevent any disease. Batch-specific Certificates of Analysis available for all products.
Selank 10mg + Semax 10mg (20mg): overview
What the vial contains and what the material is, stated as specifications rather than as outcomes.
Selank supplied as a lyophilized powder in a sealed single-use vial containing 20 mg of material. Selank: molecular weight Selank 751.9 g/mol; Semax 813.9 g/mol. Released to a specification of >99% purity by HPLC. Soluble in bacteriostatic water. Supplied for in-vitro laboratory research only. Not a drug, food or supplement. Not for human or veterinary use.
Volta does not provide dosing, administration or protocol guidance for any material listed.
Selank 10mg + Semax 10mg (20mg) specifications
Every field the product record holds. A field with no value is omitted rather than printed as a dash.
- Fill
- 20mg
- Form
- Lyophilized powder
- CAS number
- Custom Blend
- Molecular formula
- Custom Blend
- Molecular weight
- Selank 751.9 g/mol; Semax 813.9 g/mol
- Solubility
- Soluble in bacteriostatic water
- Shelf life
- 24 months from date of manufacture
Selank + Semax analytical verification and batch documentation
What the purity figure on this page is, who measured what, and which of the two a reader is looking at.
Specification. Every batch is released to >99% purity by HPLC. That is a threshold Volta sets, and it is a promise rather than a measurement.
Measurement. No certificate for this compound is published on the site yet. A batch-specific Certificate of Analysis is available on request, and the batch history lists the ones already published. Until one is published for this material, the figure above is the release specification and nothing on this page is a laboratory result.
Checking a certificate. The batch number printed beside the price is derived from the compound code and the vial strength; the lot number on a certificate is transcribed from the document. They are produced independently, so comparing them is a real check. How to read one is set out in the quality and testing methodology page.
For in-vitro laboratory research by qualified professionals only. Not for human or animal administration. Not a drug, food, cosmetic or dietary supplement. Not intended to diagnose, treat, cure, mitigate or prevent any disease.
Selank and Semax are both short regulatory peptides that emerged from the Institute of Molecular Genetics in Moscow, and both were designed by attaching a Pro-Gly-Pro tail to a bioactive parent fragment, tuftsin in the case of Selank and ACTH(4-10) in the case of Semax. That shared design is why they are so often paired in the literature: the tail confers enzymatic stability on both, while the parent fragments target distinct pathways. Supplying them in a single vial removes one reconstitution variable from co-administration protocols. Note that combined vials cannot be dosed independently, which makes them unsuitable for dose-response work on either peptide alone.
- Released to a >99% purity specification by HPLC
- Lyophilized powder, 20mg per vial
- Soluble in bacteriostatic water
- For laboratory research use only
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Related research materials
Selank 10mg + Semax 10mg (20mg): what is in the vial
The arithmetic specific to this 20mg vial, and what a milligram of Selank costs in each strength the catalogue carries. Concentrations are stated, not recommended.
Vial contents
20 mg
Lyophilised powder, reconstituted by the buyer
Cost of material
$4.10 / mg USD
CA$5.85 / mg in Canadian dollars
Concentration at each diluent volume
20 mg of dry material reaches these concentrations in the volumes below. A U-100 syringe marking is 0.01 ml by definition, so the last column is a unit conversion at each concentration rather than a quantity to use.
| Diluent added | Concentration | In 0.1 ml | Per U-100 unit |
|---|---|---|---|
| 1 ml | 20 mg/ml | 2 mg | 200 mcg |
| 2 ml | 10 mg/ml | 1 mg | 100 mcg |
| 3 ml | 6.67 mg/ml | 666.7 mcg | 66.7 mcg |
| 5 ml | 4 mg/ml | 400 mcg | 40 mcg |
For a volume this table does not list, the reconstitution calculator takes any vial size and diluent volume.
Selank purity and identity: how the figure is measured
What >99% (HPLC) means, the masses an identity check has to land on, and the entries that make a certificate of analysis checkable rather than decorative.
Stated purity
>99% (HPLC)
Area percent of the main peak by reversed-phase HPLC
What a certificate for Selank should carry
A purity percentage on its own is not checkable. These are the entries that make one verifiable, and their absence is the most common weakness in a research-peptide certificate.
The chromatogram, not only the number
A stated area percent with no trace behind it cannot be read for the shape of the main peak or for what eluted beside it. The HPLC interpreter walks through what a trace shows.
Net peptide content, separately from gross mass
A lyophilised peptide is a salt, usually of trifluoroacetic or acetic acid, plus residual water. The vial's stated milligrams are gross; net peptide content is the fraction of that mass which is the molecule. The two differ by ten to twenty percent routinely, and only one of them is what the price is per milligram of. The net peptide content calculator converts between them.
The counterion, named
Which salt form the powder is in changes the net content and the pH the powder dissolves at. A certificate that never names it leaves both unknowable.
Water content, by a stated method
Loss on drying and Karl Fischer titration give different numbers, and a water figure with no method attached cannot be compared with anyone else's.
A laboratory and a report identifier
Without both, nothing on the document can be traced back to the laboratory that issued it. The red flag checker lists the rest.
Batch certificates are published as page images in the certificate library. The source PDFs are never served: a certificate is the most forgeable document a supplier publishes, and an editable copy carrying an accredited laboratory's letterhead is worth more to a counterfeiter than to a customer.
Selank storage and stability
Handling as the product record states it, followed by the degradation chemistry this particular sequence is and is not exposed to.
Handling
Store lyophilized peptide at -20°C in a dry, dark environment. Reconstitute in bacteriostatic water. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles. Lyophilized powder is stable at room temperature for shipping and short-term storage.
A residue-level stability profile needs a primary sequence of standard amino acids. This compound's sequence carries modified or non-standard residues, so no finding is derived for it rather than one being estimated from a partial reading. The storage guide covers the general case.
Selank compared with DSIP and Epithalon
Pharmacological class, half-life, evidence grade, competition status and cost per milligram, side by side.
| Compound | Class | Half-life | Evidence | WADA | Cheapest per mg |
|---|---|---|---|---|---|
| DSIP | Sleep / Neuropeptide | ~7–8 minutes IV; longer SC | DPreclinical | Not listed | $4.6710mg vial |
| Epithalon | Anti-Aging / Telomere | Several hours | DPreclinical | Not listed | $3.4010mg vial |
| HCG | Hormonal / Reproductive | ~24-36 hours | AFDA Approved | Not listed | — |
| KPV | Anti-Inflammatory / Immune | ~2 hours (SC); shorter oral due to GI degradation | DPreclinical | Not listed | $3.9010mg vial |
| MOTS-c | Metabolic / Mitochondrial | Several hours; tissue effects may persist longer | DPreclinical | Not listed | $3.2010mg vial |
Evidence grades and half-lives are as recorded in the compound database, which cites its own sources on each compound page. Per-milligram prices are the cheapest strength each compound is currently listed at, in US dollars, and an out-of-stock note means that figure is not purchasable today. Cross-trial comparisons of efficacy are not comparisons: no head-to-head trial exists for most of these pairs.
Selank in Canada
Price in Canadian dollars, where the parcel ships from, and how long it takes.
Price in CAD
CA$117
The figure charged, not a converted estimate
Ships from
British Columbia
A domestic parcel, so no import clearance step
Transit
2 to 5 business days
After 1 to 2 business days of handling
Free standard shipping
Over CA$250
A bar set for this market, not converted from the US one
Selank 10mg + Semax 10mg (20mg) ships from British Columbia to Canadian addresses, so the parcel never crosses a border. That removes the failure a Canadian buyer of research peptides is usually weighing: an inbound international shipment can be held for import clearance or seized, and a domestic one has no clearance step to be held at.
Shipping is quoted live against the delivery address at checkout rather than estimated here, and both the standard and express tiers show their price and transit window before a payment method is chosen. The figure the page shows is the figure the rail charges: all three settlement rails price shipping through the same functions the quote does.
The Canadian figure above is not a loose conversion. Each product's US dollar base is chosen so that the live conversion lands on the Canadian shelf price set for this market, and the result is pushed up to a whole dollar rather than left carrying cents, so one figure serves the page, the feed and every payment rail. See the shipping policy for carriers and cut-off times, and the legal position on research peptides in Canada for the regulatory picture.
Selank and Semax Blend Mechanism of Action
This is a combination vial containing selank and semax, two synthetic heptapeptides developed at the same Russian institute and sharing a common design principle. They are not variants of one molecule: selank derives from the immunomodulatory tetrapeptide tuftsin, semax from the ACTH(4-10) fragment, and their reported actions are on different systems. What they share is a structural trick and a research tradition.
The trick is the C-terminal Pro-Gly-Pro. Both sequences end in that tripeptide, appended to a biologically active parent fragment. Native tuftsin and native ACTH(4-10) are both degraded rapidly by peptidases; the Pro-Gly-Pro extension confers resistance, and the glyproline itself is reported to be bioactive rather than inert. Selank is Thr-Lys-Pro-Arg followed by Pro-Gly-Pro; semax is Met-Glu-His-Phe followed by Pro-Gly-Pro. Read side by side, the shared tail is the whole family resemblance.
Their reported mechanisms diverge from there. Semax has been reported to regulate brain-derived neurotrophic factor and its receptor TrkB, to induce neurotrophin messenger RNAs in glial cultures, and to bind specifically in brain tissue. Selank has been reported to inhibit enkephalin-degrading enzymes, raising endogenous enkephalin availability, alongside effects on behavioural measures. Neurotrophic signalling and enkephalinase inhibition are unrelated mechanisms, and the combination has not been studied as such.
Shared Pro-Gly-Pro tail
Both peptides append the glyproline Pro-Gly-Pro to an active parent fragment, conferring resistance to peptidase degradation that the parent fragments lack.
Semax: neurotrophin regulation
Reported regulation of brain-derived neurotrophic factor and TrkB expression, and rapid induction of neurotrophin messenger RNAs in glial cultures.
Semax: specific brain binding
Reported specific binding in brain tissue, distinguishing it from a purely metabolic or nonspecific action.
Selank: enkephalinase inhibition
Reported inhibition of enkephalin-degrading enzymes, which would raise the availability of endogenous enkephalins rather than acting as an opioid receptor ligand itself.
Unstudied in combination
The two mechanisms are unrelated, and no study has examined the peptides together. Any account of the blend is an account of two separate literatures.
Blend Constituent Research Findings
Each finding belongs to one constituent studied alone, and the literature for both is overwhelmingly Russian-language preclinical work. None used the combination.
Semax reported to regulate BDNF and TrkB expression
Work in rat brain reported that the ACTH(4-10) analogue regulates brain-derived neurotrophic factor and its receptor, which is the most cited mechanistic finding for this peptide. Studied as semax alone.
Rodent modelSemax binds specifically in brain tissue
A neurochemistry study reported specific binding of the analogue in brain, supporting a targeted interaction rather than a nonspecific effect. Studied as semax alone.
In vitroRapid induction of neurotrophin messenger RNAs in glial cultures
Semax induced neurotrophin transcripts in rat glial cell cultures on a short timescale, indicating an effect on gene expression rather than only on existing protein. Studied as semax alone.
In vitroSelank inhibits enkephalin-degrading enzymes
Work reported inhibition of enkephalin-degrading enzymes as a proposed mechanism, which would act by preserving endogenous enkephalins rather than by binding opioid receptors directly. Studied as selank alone.
Rodent modelSelank effects on behavioural measures alongside enzyme activity
A study examined behavioural reactions together with plasma enkephalin-degrading enzyme activity, linking the biochemical mechanism to a measured behavioural readout in the same work. Studied as selank alone.
Rodent modelGlyproline distribution characterised after administration
Comparative analysis of the distribution of glyprolines following different administration routes characterised where these peptides and their fragments go, which is the pharmacokinetic basis for the Pro-Gly-Pro design.
Rodent modelBlend Composition
| Product Type | Two-peptide combination vial, not a single chemical entity |
| Stated Constituents | Selank and semax |
| Total Peptide Mass | 20mg per vial |
| Constituent Ratio | Not disclosed on the product listing |
| CAS Number | Not applicable. A mixture has no single CAS number |
| Selank Component | Thr-Lys-Pro-Arg-Pro-Gly-Pro, 751.9 g/mol, CAS 129954-34-3 |
| Semax Component | Met-Glu-His-Phe-Pro-Gly-Pro, 813.93 g/mol, CAS 80714-61-0 |
| Shared Motif | Both end in the glyproline Pro-Gly-Pro |
| Parent Fragments | Tuftsin for selank, ACTH(4-10) for semax |
| Mass Separation | Approximately 62 daltons, the narrowest of any blend in this catalogue |
The Shared Tail Is the Family Resemblance
Selank and semax look unrelated until they are written out. Selank is Thr-Lys-Pro-Arg-Pro-Gly-Pro. Semax is Met-Glu-His-Phe-Pro-Gly-Pro. The first four residues differ completely, because they come from different parent molecules: tuftsin, an immunomodulatory tetrapeptide, and ACTH(4-10), a fragment of adrenocorticotropic hormone.
The last three are identical. Pro-Gly-Pro is a glyproline appended deliberately to both, and its purpose is pharmacokinetic: native tuftsin and native ACTH(4-10) are cleared rapidly by peptidases, and the extension confers resistance. This is the same design problem solved for GHRH analogues by a D-amino acid substitution and for GLP-1 by a non-natural residue, approached differently.
The glyproline is also reported to be bioactive in its own right rather than an inert handle, which complicates attribution. An effect observed with either peptide could in principle involve the shared tail or its liberated fragment, which is a reason to be careful about ascribing an effect to the parent sequence alone.
This Is the Hardest Blend Here to Verify by Mass
The two-component vials elsewhere in this catalogue are analytically comfortable: BPC-157 and TB-500 differ by about 530 daltons, the GHRH analogue and ipamorelin by about 2,650. Selank and semax differ by roughly 62 daltons, which is a much narrower separation.
Sixty-two daltons is still well within the resolving power of ordinary mass spectrometry, so the two are distinguishable. But the margin is small enough that adducts, oxidation products and related substances can fall in the same neighbourhood. Semax contains a methionine, and methionine oxidation adds 16 daltons, so an oxidised semax species sits between the two parent masses.
The practical consequence is that this blend rewards a proper analytical method more than the others do. A low-resolution instrument or a poorly chosen gradient will produce a trace that is harder to interpret confidently than the equivalent trace for a widely separated pair.
A Literature That Is Real but Hard to Read
Both compounds have genuine published pharmacology, which distinguishes them from several compounds sold alongside them. Much of it appears in Russian-language journals such as Bulletin of Experimental Biology and Medicine and Russian Journal of Bioorganic Chemistry, and originates from a small number of institutes.
That is not a reason to dismiss the work, and it is not the same criticism as fabricated citations. It does mean the usual caveat about independent replication applies with particular force: findings repeated within one research tradition are less robust than findings reproduced by groups with different assumptions and reagents.
Neither compound is approved in any Western jurisdiction, and no controlled study has examined the combination. Material supplied for research is for in-vitro laboratory use only.
Handling a Two-Component Vial
Semax contains a methionine and is therefore the oxidation-sensitive constituent of the pair. Selank has no oxidation-prone residue. A blend is only as stable as its least stable component, so storage conditions for this vial are effectively set by the semax fraction.
Both peptides are proline-rich, with three prolines in selank and two in semax, so cis-trans isomerism can broaden chromatographic peaks for either. Combined with the narrow mass separation, that is a further reason to read a purity figure for this blend alongside the method that produced it.
Blend Research FAQ
Selank and Semax Blend in Summary
A two-peptide vial of selank and semax, heptapeptides from different parents that share a deliberately appended Pro-Gly-Pro tail conferring peptidase resistance. Their reported mechanisms, enkephalinase inhibition and neurotrophin regulation, are unrelated.
At roughly 62 daltons apart they are the narrowest-separated pair in this catalogue, and semax oxidation lands between the two parent masses, so this blend rewards a proper analytical method more than the widely separated pairs do.
Scientific References
Primary literature and public trial registries only. No supplier or retailer pages are cited.
- 1Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampusDolotov OV, Karpenko EA, Inozemtseva LS, et al. · Brain Research · 2006
- 2Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrainDolotov OV, Karpenko EA, Seredenina TS, et al. · Journal of Neurochemistry · 2006
- 3Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analogShadrina MI, Dolotov OV, Grivennikov IA, et al. · Neuroscience Letters · 2001
- 4The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activityZozulya AA, Neznamov GG, Siuniakov TS, et al. · Bulletin of Experimental Biology and Medicine · 2001
- 5Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in miceKozlovskaia MM, Kozlovskii II, Val'dman EA, Seredenin SB · Bulletin of Experimental Biology and Medicine · 2002
- 6A comparative analysis of distribution of glyprolines administered by different routesShevchenko KV, Nagaev IY, Andreeva LA, et al. · Russian Journal of Bioorganic Chemistry · 2008
Disclaimer
All articles and product information provided on this website are for informational and educational purposes only. The products offered on this website are furnished for in-vitro studies only. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.
Selank 10mg + Semax 10mg (20mg): frequently asked questions
Answered from the product record and the certificate file. Volta does not answer questions about administration, dosing or protocols.
What is supplied in a 20 mg vial of Selank + Semax?
A sealed single-use vial containing 20 mg of Selank as a lyophilized powder. Soluble in bacteriostatic water. No diluent, syringe or other supply is included.
Is Selank + Semax supplied for human use?
No. For in-vitro laboratory research by qualified professionals only. Not for human or animal administration. Not a drug, food, cosmetic or dietary supplement. Not intended to diagnose, treat, cure, mitigate or prevent any disease. Volta does not provide dosing, administration or protocol guidance for any material listed.
What purity is this Selank + Semax released to?
>99% by HPLC. That figure is a release specification, a threshold Volta sets for every batch, and it is not the same kind of statement as a purity measured by a named laboratory for a named lot.
Is there a certificate of analysis for this Selank + Semax vial?
A batch-specific Certificate of Analysis is available for this product on request. It is not published on the site yet: the batch history on the quality page lists the certificates already published, and this vial is covered by the release specification until its own is added there.
How is Selank + Semax identified?
molecular weight Selank 751.9 g/mol; Semax 813.9 g/mol. Those identifiers are what an incoming-goods check compares a certificate against, and they are stated here so the comparison can be made before ordering.
How should Selank + Semax be stored before reconstitution?
Store lyophilized peptide at -20°C in a dry, dark environment. Reconstitute in bacteriostatic water. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles. Lyophilized powder is stable at room temperature for shipping and short-term storage.
Where does this ship from?
British Columbia, Canada. Canadian orders are domestic, so they clear no customs and pay no import duty. International orders ship from the same facility.
Related Research News
Boost Focus and Clarity with Selank and Semax Duo
Selank and Semax, synthetic peptides from Russian research labs, offer complementary cognitive benefits. Selank reduces anxiety and sharpens attention by balancing neurotransmitters and upregulating BDNF. Semax sustains focus through neuroprotection and neurotrophin enhancement, with studies showing improved memory under stress when used together.
Zepbound in Peptide Research: Sleep, Mood, and Metabolic Context
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Zepbound: A Research Perspective on Cognitive Peptides and Focus
Zepbound is a term associated with research into cognitive peptides and nootropic compounds. This article explores the preclinical evidence behind peptides like Semax, Selank, and Pinealon, which are studied for their effects on BDNF expression, neuroprotection, and synaptic plasticity. Learn how Volta Peptides supports researchers with verified compounds and tools for reliable experimentation.
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