ACE-031 1mg Peptide
Research Use Only
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Research Use Only
For in vitro laboratory research by qualified professionals only. Not for human or animal administration. Not intended to treat, prevent, mitigate, or cure any disease. Batch-specific Certificates of Analysis available for all products.
Research Use Only
For in vitro laboratory research by qualified professionals only. Not for human or animal administration. Not intended to treat, prevent, mitigate, or cure any disease. Batch-specific Certificates of Analysis available for all products.
Rather than blocking myostatin at the receptor, ACE-031 removes it from circulation: the ActRIIB extracellular domain binds myostatin, activin A and GDF-11 with high affinity, and the Fc fusion gives the construct a long half-life. That broad ligand promiscuity is both its strength as a research tool and the reason its clinical development in Duchenne muscular dystrophy was halted, since off-target ligand sequestration produced vascular effects. It is a large recombinant fusion protein, not a peptide, and requires strict cold-chain handling and gentle reconstitution to avoid denaturation.
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