Key Takeaways
- •Contract research and development manufacturing organizations provide solutions for nucleic acids, peptides, and synthetic conjugates.
- •Catalogs cover nucleotides, amino acids, amidites, and custom builders.
- •Nucleic acid catalogs support progression from discovery to development and commercial manufacturing.
Essential Building Blocks for Nucleic Acids and Peptides
Contract research and development manufacturing organizations provide solutions for nucleic acids, peptides, and synthetic conjugates. These offerings include building blocks suitable for stages from discovery to commercialization. Such products enable faster and more cost-effective development.
Catalogs cover nucleotides, amino acids, amidites, and custom builders. Researchers access categories like ASO amidites, RNA amidites, PMO monomers, and siRNA amidites. Additional series include specialty DNA amidites, base modifications, and skeletal modifications.
Nucleic Acid Product Categories
Nucleic acid catalogs support progression from discovery to development and commercial manufacturing. Key categories consist of Adenine Series, Thymine Series, Cytosine Series, Guanine Series, Uracil Series, and Inosine Series. Other groups feature Abasic Series, Reverse Amidite, α-DNA Series, L-DNA Amidite, and L-RNA Amidite.
Further modifications include 2'-amidite Series, 2'-OMe Series, 2'-F Series, 2'-MOE Series, 2'-OH Series, 2'-amino Series, 2'-aminoethyl Series, and 2'-NMA Series. Advanced options cover LNA Series, GNA Series, TNA Series, UNA Series, ENA Series, Me-P Series, PACE Series, and OMe-P Series. Modifiers encompass Amino Modifiers, Thiol Modifiers, Phosphate Modifiers, and Spacer Modifiers.
Nucleotides and precursors include Canonical NTP, Mono- and Di-Nucleotides, Cap Precursors, 7-Methyl Guanosine Reagents, 2'-OBn Series, Base Modified dNTP, Sugar Modified NTP, Deoxynucleotide Diphosphate (dNDP), and Deoxynucleotides (dNTPs). For more on peptide-related terms, check the Peptide Glossary.
Highlighted Amidite Products
Specific nucleic acid amidites demonstrate high purity levels. For instance, 2'-MOE A(Bz) amidite, catalog ID STA-AM10009, has molecular formula C50H58N7O9P, CAS 251647-53-7, and purity >99%. Similarly, 2'-MOE G(iBu) amidite, STA-AM10010, formula C47H60N7O10P, CAS 251647-55-9, purity >99%.
DNA T amidite, STA-AM10001, Thymine Series, C40H49N4O8P, CAS 98796-51-1, purity >99%. 2'-OMe C(Ac) amidite, STA-AM10015, 2'-OMe Series, C42H52N5O9P, CAS 199593-09-4, purity >99%. 2'-OMe G(iBu) amidite, STA-AM10017, C45H56N7O9P, CAS 150780-67-9, purity >99%.
2'-F A(Bz) amidite, STA-AM10023, 2'-F Series, C47H51FN7O7P, CAS 136834-22-5, purity >99%. DNA A(Bz) amidite, STA-AM10003, Adenine Series, C47H52N7O7P, CAS 98796-53-3, purity >99%. 2'-F C(Ac) amidite, STA-AM10021, C41H49FN5O8P, CAS 159414-99-0, purity >99%.
Additional Specialized Amidites
2'-F U amidite, STA-AM10019, 2'-F Series, C39H46FN4O8P, CAS 146954-75-8, purity >99%. 2'-F G(iBu) amidite, STA-AM10024, C44H53FN7O8P, CAS 144089-97-4, purity >99%. 2'-MOE MeC(Bz) amidite, STA-AM10007, 2'-MOE Series, C50H60N5O10P, CAS 163759-94-2, purity >99%.
2'-OMe A(Bz) amidite, STA-AM10016, 2'-OMe Series, C48H54N7O8P, CAS 110782-31-5, purity >99%. 2'-OMe U amidite, STA-AM10011, C40H49N4O9P, CAS 110764-79-9, purity >99%. 2'-MOE T amidite, STA-AM10006, C43H55N4O10P, CAS 163878-63-5, purity >99%.
DNA C(Bz) amidite, STA-AM10002, Cytosine Series, C46H52N5O8P, CAS 102212-98-6, purity >99%. DNA G(iBu) amidite, STA-AM10004, Guanine Series, C44H54N7O8P, CAS 93183-15-4, purity >99%. Explore dosing tools at the Dosage & Cycle Planner.
LNA and Inosine Amidites
LNA G(dmf) amidite, STA-AM10028, LNA Series, C44H53N8O8P, CAS 709641-79-2, purity >99%. LNA A(Bz) amidite, STA-AM10027, C48H52N7O8P, CAS 206055-79-0, purity >99%. 2'-OMe I amidite, STA-AM10117, Inosine Series, C41H49N6O8P, CAS 128219-85-2, purity >98%.
LNA T amidite, STA-AM10025, LNA Series, C41H49N4O9P, CAS 206055-75-6, purity >99%. LNA MeC(Bz) amidite, STA-AM10093, C48H54N5O9P, CAS 206055-82-5, purity >99%. 2'-MOE I amidite, STA-AM10920, Inosine Series, C43H53N6O9P, CAS No data, purity >98%.
2'-MOE A(Bz) amidite repeats as STA-AM10009, C50H58N7O9P, CAS 251647-53-7, purity >99%.
Amino Acid Categories and Capabilities
Amino acid catalogs span from discovery to manufacturing. Categories include Derivative of Natural AA, Side Chain Modified AA, Unusual AA, Backbone Modified AA, Unnatural AA, Alpha-alkylated, Homo-natural AA, Alkenyl AA, Azido/Alkynyl AA, and Lipidated AA.
Platforms offer scalability from discovery to commercialization with large capacity. Integrated CMC covers API process R&D, manufacturing, formulation, analytical services, dossier preparation, and clinical supplies. Comprehensive analytical platforms handle method development, validation, IPC, release testing, characterization, and stability.
New technologies support oligonucleotide synthesis via biocatalysis for gRNA and Thin Film Evaporation (TFE). Peptide processes use reactor-in-series with PAT data, continuous flow chromatography, and Tangential Flow Filtration (TFF)/precipitation. Global quality standards apply across sites, approved by major agencies. Conjugation chemistry enables collaboration among teams. Browse our catalog for related research compounds.
