MK-677 Dosing & Reconstitution Guide
Dosing Protocol
Route: Oral (capsule or liquid) Frequency: Once daily Dose Range: 10–25 mg/day orally Cycle Length: 8–12 weeks on, 4 weeks off; some protocols run up to 6 months with monitoring Timing: Before bed (promotes deep sleep and aligns with natural GH pulse); some prefer morning if appetite increase is problematic at night
Titration Schedule
Weeks 1–2: 10 mg daily (assess tolerance) Weeks 3+: 15–25 mg daily
Storage
Lyophilized: Room temperature, cool and dry (oral formulation) Reconstituted: N/A — oral capsules/liquid do not require reconstitution
Safety & Contraindications
Safety: Common: increased appetite (ghrelin agonism), water retention/mild edema, transient muscle pain Metabolic: may elevate fasting blood glucose and reduce insulin sensitivity (dose-dependent); important for diabetics and pre-diabetics Fatigue and lethargy reported by some users
Contraindications: Diabetes or significant insulin resistance (may worsen glucose control); Active cancer (elevated GH/IGF-1 may promote tumor growth); Pregnancy and breastfeeding