Snap-8 10mg Peptide
For in-vitro laboratory research only. Not for human or animal administration.
Batch #: VPS810100
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Research Use Only
For in-vitro laboratory research by qualified professionals only. Not for human or animal administration. Not a drug, food, cosmetic or dietary supplement. Not intended to diagnose, treat, cure, mitigate or prevent any disease. Batch-specific Certificates of Analysis available for all products.
Snap-8 10mg: overview
What the vial contains and what the material is, stated as specifications rather than as outcomes.
Snap-8 supplied as a lyophilized powder in a sealed single-use vial containing 10 mg of material. Snap-8: molecular formula C₄₁H₇₀N₁₆O₁₆S, molecular weight 1,075.17 g/mol, CAS 868844-74-0. Released to a specification of >99% purity by HPLC. Soluble in bacteriostatic water. Supplied for in-vitro laboratory research only. Not a drug, food or supplement. Not for human or veterinary use.
Volta does not provide dosing, administration or protocol guidance for any material listed.
Snap-8 10mg specifications
Every field the product record holds. A field with no value is omitted rather than printed as a dash.
- Fill
- 10mg
- Form
- Lyophilized powder
- CAS number
- 868844-74-0
- Molecular formula
- C₄₁H₇₀N₁₆O₁₆S
- Molecular weight
- 1,075.17 g/mol
- Solubility
- Soluble in bacteriostatic water
- Shelf life
- 24 months from date of manufacture
Snap-8 analytical verification and batch documentation
What the purity figure on this page is, who measured what, and which of the two a reader is looking at.
Specification. Every batch is released to >99% purity by HPLC. That is a threshold Volta sets, and it is a promise rather than a measurement.
Measurement. No certificate for this compound is published on the site yet. A batch-specific Certificate of Analysis is available on request, and the batch history lists the ones already published. Until one is published for this material, the figure above is the release specification and nothing on this page is a laboratory result.
Checking a certificate. The batch number printed beside the price is derived from the compound code and the vial strength; the lot number on a certificate is transcribed from the document. They are produced independently, so comparing them is a real check. How to read one is set out in the quality and testing methodology page.
For in-vitro laboratory research by qualified professionals only. Not for human or animal administration. Not a drug, food, cosmetic or dietary supplement. Not intended to diagnose, treat, cure, mitigate or prevent any disease.
Snap-8 mimics the N-terminal region of SNAP-25, the SNARE protein that botulinum toxin cleaves. Rather than cutting the protein, it competes for a position in the ternary SNARE complex, which destabilises vesicle fusion. That competitive, reversible mechanism is why the peptide is studied as a topical research analogue for neuromuscular signalling work. The two additional residues relative to Argireline are reported to increase affinity for the complex. This is a cosmetic-chemistry research material, used at low concentration in formulation and cell-culture studies.
- Released to a >99% purity specification by HPLC
- Lyophilized powder, 10mg per vial
- Soluble in bacteriostatic water
- For laboratory research use only
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Snap-8 10mg: what is in the vial
The arithmetic specific to this 10mg vial, and what a milligram of Snap-8 costs in each strength the catalogue carries. Concentrations are stated, not recommended.
Vial contents
10 mg
Lyophilised powder, reconstituted by the buyer
Cost of material
$3.20 / mg USD
CA$4.60 / mg in Canadian dollars
Concentration at each diluent volume
10 mg of dry material reaches these concentrations in the volumes below. A U-100 syringe marking is 0.01 ml by definition, so the last column is a unit conversion at each concentration rather than a quantity to use.
| Diluent added | Concentration | In 0.1 ml | Per U-100 unit |
|---|---|---|---|
| 1 ml | 10 mg/ml | 1 mg | 100 mcg |
| 2 ml | 5 mg/ml | 500 mcg | 50 mcg |
| 3 ml | 3.33 mg/ml | 333.3 mcg | 33.3 mcg |
| 5 ml | 2 mg/ml | 200 mcg | 20 mcg |
For a volume this table does not list, the reconstitution calculator takes any vial size and diluent volume.
Snap-8 purity and identity: how the figure is measured
What >99% (HPLC) means, the masses an identity check has to land on, and the entries that make a certificate of analysis checkable rather than decorative.
Stated purity
>99% (HPLC)
Area percent of the main peak by reversed-phase HPLC
Average mass
1,075.17 g/mol
The figure an identity check has to land on
Identity by mass: the ions to expect
An electrospray source protonates the molecule rather than weighing it neutral, so a spectrum shows a series of charge states rather than the molecular weight itself. These are the m/z values 1,075.17 g/mol produces, and they are what a mass spectrum on a certificate for Snap-8 has to match.
| Ion | Charge | Expected m/z |
|---|---|---|
| [M+H]+ | 1+ | 1,076.18 |
What a certificate for Snap-8 should carry
A purity percentage on its own is not checkable. These are the entries that make one verifiable, and their absence is the most common weakness in a research-peptide certificate.
The chromatogram, not only the number
A stated area percent with no trace behind it cannot be read for the shape of the main peak or for what eluted beside it. The HPLC interpreter walks through what a trace shows.
Net peptide content, separately from gross mass
A lyophilised peptide is a salt, usually of trifluoroacetic or acetic acid, plus residual water. The vial's stated milligrams are gross; net peptide content is the fraction of that mass which is the molecule. The two differ by ten to twenty percent routinely, and only one of them is what the price is per milligram of. The net peptide content calculator converts between them.
The counterion, named
Which salt form the powder is in changes the net content and the pH the powder dissolves at. A certificate that never names it leaves both unknowable.
Water content, by a stated method
Loss on drying and Karl Fischer titration give different numbers, and a water figure with no method attached cannot be compared with anyone else's.
A laboratory and a report identifier
Without both, nothing on the document can be traced back to the laboratory that issued it. The red flag checker lists the rest.
Batch certificates are published as page images in the certificate library. The source PDFs are never served: a certificate is the most forgeable document a supplier publishes, and an editable copy carrying an accredited laboratory's letterhead is worth more to a counterfeiter than to a customer.
Snap-8 storage and stability
Handling as the product record states it, followed by the degradation chemistry this particular sequence is and is not exposed to.
Handling
Store lyophilized peptide at -20°C in a dry, dark environment. Reconstitute in bacteriostatic water. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles. Lyophilized powder is stable at room temperature for shipping and short-term storage.
A residue-level stability profile needs a primary sequence of standard amino acids. This compound's sequence carries modified or non-standard residues, so no finding is derived for it rather than one being estimated from a partial reading. The storage guide covers the general case.
Snap-8 compared with AHK-Cu (Copper AHK) and GHK-Cu
Pharmacological class, half-life, evidence grade, competition status and cost per milligram, side by side.
| Compound | Class | Half-life | Evidence | WADA | Cheapest per mg |
|---|---|---|---|---|---|
| Snap-8this page | Cosmetic Peptide | Not established | FNo Regulatory Activity | Not listed | $3.2010mg vial, out of stock |
| AHK-Cu (Copper AHK) | Cosmetic / Research | Not established | DPreclinical Only | Not listed | $0.64100mg vial, out of stock |
| GHK-Cu | Skin & Tissue Repair | ~30 minutes plasma | FNo Regulatory Activity | Not listed | $0.59100mg vial |
| Melanotan II | Melanocortin Agonist | ~36 minutes IV; longer SC due to depot effect | FNo Regulatory Activity | Prohibited | $3.2010mg vial |
Evidence grades and half-lives are as recorded in the compound database, which cites its own sources on each compound page. Per-milligram prices are the cheapest strength each compound is currently listed at, in US dollars, and an out-of-stock note means that figure is not purchasable today. Cross-trial comparisons of efficacy are not comparisons: no head-to-head trial exists for most of these pairs.
Snap-8 in Canada
Price in Canadian dollars, where the parcel ships from, and how long it takes.
Price in CAD
CA$46
The figure charged, not a converted estimate
Ships from
British Columbia
A domestic parcel, so no import clearance step
Transit
2 to 5 business days
After 1 to 2 business days of handling
Free standard shipping
Over CA$250
A bar set for this market, not converted from the US one
Snap-8 10mg ships from British Columbia to Canadian addresses, so the parcel never crosses a border. That removes the failure a Canadian buyer of research peptides is usually weighing: an inbound international shipment can be held for import clearance or seized, and a domestic one has no clearance step to be held at.
Shipping is quoted live against the delivery address at checkout rather than estimated here, and both the standard and express tiers show their price and transit window before a payment method is chosen. The figure the page shows is the figure the rail charges: all three settlement rails price shipping through the same functions the quote does.
The Canadian figure above is not a loose conversion. Each product's US dollar base is chosen so that the live conversion lands on the Canadian shelf price set for this market, and the result is pushed up to a whole dollar rather than left carrying cents, so one figure serves the page, the feed and every payment rail. See the shipping policy for carriers and cut-off times, and the legal position on research peptides in Canada for the regulatory picture.
SNAP-8 Mechanism of Action
SNAP-8 is an acetylated octapeptide, an extension by two residues of the hexapeptide sold as Argireline. Both are designed to mimic the N-terminal region of SNAP-25, one of the three proteins that form the SNARE complex responsible for docking and fusing neurotransmitter vesicles at the presynaptic membrane.
The proposed mechanism is competitive interference. SNARE-mediated fusion requires SNAP-25, syntaxin and VAMP to assemble into a ternary complex. A peptide resembling the SNAP-25 N-terminus can in principle occupy a position in that assembly without supporting fusion, destabilising the complex and reducing vesicle docking. That is a fundamentally different approach from botulinum toxin, which cleaves SNAP-25 enzymatically and irreversibly.
The distinction matters for how the two should be compared. Enzymatic cleavage is catalytic and long-lasting; competitive occupancy is stoichiometric and reversible, requiring the peptide to be present in sufficient quantity at the site to have any effect. For a topically applied peptide that raises the obvious question of whether enough reaches the relevant membrane, and that question is not answered anywhere in the indexed literature for this molecule.
SNARE assembly
Vesicle fusion at the presynaptic membrane requires SNAP-25, syntaxin and VAMP to assemble into a ternary SNARE complex.
N-terminal mimicry
The peptide is designed to resemble the N-terminal region of SNAP-25, the region that participates in that assembly.
Competitive occupancy
By occupying a position in the complex without supporting fusion, the peptide is proposed to destabilise assembly and reduce vesicle docking.
Reversible, not catalytic
Unlike botulinum toxin, which cleaves SNAP-25 enzymatically, this mechanism is stoichiometric and reversible, so it depends on sufficient peptide reaching the site.
Delivery is the open question
A peptide acting by occupancy must be present in quantity at a presynaptic membrane. Nothing in the indexed literature addresses whether that occurs for this molecule.
Argireline and SNARE Research Findings
No entry below used SNAP-8. They concern the shorter parent peptide and the exocytosis machinery the mechanism assumes, and each says which.
Acetyl hexapeptide combined with another peptide assessed for efficacy
A study examined the efficacy of a combination of tripeptide-10-citrulline and acetyl hexapeptide-3 in a cosmetic setting. It concerns the shorter parent peptide, and as a combination it cannot isolate that peptide's contribution.
ObservationalAcetyl hexapeptide-8 examined in scar and wrinkle camouflage
Work on temporary camouflage of skin scars and wrinkles in dermatology and oncoesthetics focused on acetyl hexapeptide preparations, again the shorter parent rather than the octapeptide.
ObservationalAcetyl hexapeptide-8 delivered on bioactive sutures
A study combined polydioxanone bioactive sutures with acetyl hexapeptide-8, addressing the delivery problem directly by placing the peptide rather than applying it topically.
ObservationalReal-world clinical experience with a neuropeptide serum
A clinical experience report described use of a neuropeptide-containing serum in combination with other treatments. Combination use and an uncontrolled design limit what it can establish about any single ingredient.
ObservationalMolecular basis of SNARE-mediated vesicle fusion inhibition
Work on the molecular basis for inhibition of synaptic vesicle fusion characterised how the SNARE complex can be blocked, which is the machinery this peptide class is designed to interfere with.
In vitroStapled peptides screened for inhibition of triggered exocytosis
A screen of hydrocarbon-stapled peptides for inhibition of calcium-triggered exocytosis demonstrates that peptide-based interference with this machinery is achievable, using a chemistry designed specifically to hold a peptide in its active conformation.
In vitroSNAP-8 Molecular Information
| Class | Acetylated octapeptide, a cosmetic ingredient |
| INCI Name | Acetyl octapeptide-3 |
| Relationship to Argireline | A two-residue extension of acetyl hexapeptide-3, also called acetyl hexapeptide-8 |
| Mimics | The N-terminal region of SNAP-25, a SNARE complex protein |
| Proposed Mechanism | Competitive, reversible interference with SNARE complex assembly |
| Contrast with Botulinum Toxin | That cleaves SNAP-25 enzymatically and irreversibly; this occupies a position reversibly |
| CAS Number | Not stated on the product listing |
| N-terminal Modification | Acetylated, which is part of the identity rather than optional |
| Appearance | White lyophilised powder |
The Compound Itself Has Not Been Studied
This is the central fact and it should be stated before anything else. Searching PubMed for SNAP-8 and for acetyl octapeptide-3 returns nothing. There is no published pharmacology, no cosmetic trial, and no analytical characterisation of this specific molecule in the indexed literature.
What exists is literature on the shorter parent peptide, Argireline, and literature on the SNARE machinery the mechanism assumes. Both are genuinely relevant, and neither is evidence about the octapeptide. The two extra residues are the entire difference between the studied molecule and this one, and nobody has published on whether they help, hurt or do nothing.
A page that presented the Argireline literature as though it described SNAP-8 would be doing exactly what this catalogue criticises elsewhere. The sources are listed with their subject stated so the inference is left to the reader.
Competitive Occupancy Is a Harder Trick Than Cleavage
The comparison to botulinum toxin is made constantly for this peptide class, and it flatters the peptide. Botulinum toxin is an enzyme: one molecule cleaves many SNAP-25 molecules and the effect persists until the protein is resynthesised. That is catalytic amplification.
A competitive peptide has no amplification. It must be present in sufficient concentration, at the right place, for as long as the effect is wanted, and it is displaced as its concentration falls. The arithmetic of how much peptide must reach a presynaptic membrane through intact skin is the obvious question, and it is unanswered here.
The stapled peptide work is instructive by contrast. That approach uses a hydrocarbon staple specifically to hold a short peptide in its bound conformation and improve its cellular access, which is an acknowledgement of how difficult the unmodified version of this task is.
A Cosmetic Ingredient Rather Than a Research Compound
SNAP-8 is a cosmetic ingredient with an INCI name, sold into formulation rather than into pharmacology. That explains the shape of its evidence base: cosmetic ingredients are not required to demonstrate mechanism, and the studies that do exist for the parent peptide are small, often uncontrolled, and frequently examine combination products.
It also explains the absence of analytical literature. There is no pharmacopoeial monograph, no reference standard in common use, and no published characterisation to compare a certificate against.
It has no approval as a medicine anywhere, because it is not one. Material supplied for research is for in-vitro laboratory use only, and nothing here is guidance for use in humans or animals.
Handling and Analytical Considerations
The N-terminal acetylation is part of the specification. A free-amine version differs in mass by 42 daltons and is a different molecule, so the reported mass distinguishes the intended product from a plausible synthesis-related variant.
With no CAS number on the listing and no published reference characterisation, the certificate's mass and sequence confirmation carry the whole identity burden for this compound. There is nothing external to check them against, which is a materially weaker position than for a compound with a pharmacopoeial or literature reference.
SNAP-8 Research FAQ
SNAP-8 in Summary
SNAP-8 is an acetylated octapeptide, a two-residue extension of Argireline, designed to mimic the SNAP-25 N-terminus and competitively destabilise SNARE complex assembly. That mechanism is reversible and stoichiometric rather than catalytic like botulinum toxin.
The molecule itself has no indexed primary literature. What exists concerns the shorter parent peptide and the SNARE machinery, and the delivery question that the mechanism raises most obviously is unanswered anywhere.
Scientific References
Primary literature and public trial registries only. No supplier or retailer pages are cited.
SNAP-8, also called acetyl octapeptide-3, has no indexed primary literature of its own. Searches for the trade name and for the INCI name return nothing on PubMed. The references below cover the two things that can honestly be cited: the shorter parent peptide Argireline, acetyl hexapeptide-3 or -8, which has been studied in cosmetic settings, and the SNARE exocytosis machinery the mechanism is built on. No study listed here used SNAP-8 itself.
- 1The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3Raikou V, Varvaresou A, Panderi I, Papageorgiou E · Journal of Cosmetic Dermatology · 2017
- 2Skin scars and wrinkles temporary camouflage in dermatology and oncoesthetics: focus on acetyl hexapeptide-8Palmieri B, Noviello A, et al. · Clinica Terapeutica · 2020
- 3Polydioxanone Bioactive Sutures with Acetyl Hexapeptide-8 (Argireline): An Intelligent SystemVelazco de Maldonado GJ, Suárez-Vega DV, et al. · Journal of Cutaneous and Aesthetic Surgery · 2023
- 4Real-World Clinical Experience With a Neuro-Peptide Serum in Combination With Other TreatmentsLupin M, Bjerring P, et al. · Journal of Drugs in Dermatology · 2024
- 5Molecular basis for G beta gamma-SNARE-mediated inhibition of synaptic vesicle fusionEitel AR, Mueller BK, et al. · Journal of Biological Chemistry · 2025
- 6Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered ExocytosisLai Y, Tuvim MJ, et al. · Frontiers in Pharmacology · 2022
Disclaimer
All articles and product information provided on this website are for informational and educational purposes only. The products offered on this website are furnished for in-vitro studies only. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.
Snap-8 10mg: frequently asked questions
Answered from the product record and the certificate file. Volta does not answer questions about administration, dosing or protocols.
What is supplied in a 10 mg vial of Snap-8?
A sealed single-use vial containing 10 mg of Snap-8 as a lyophilized powder. Soluble in bacteriostatic water. No diluent, syringe or other supply is included.
Is Snap-8 supplied for human use?
No. For in-vitro laboratory research by qualified professionals only. Not for human or animal administration. Not a drug, food, cosmetic or dietary supplement. Not intended to diagnose, treat, cure, mitigate or prevent any disease. Volta does not provide dosing, administration or protocol guidance for any material listed.
What purity is this Snap-8 released to?
>99% by HPLC. That figure is a release specification, a threshold Volta sets for every batch, and it is not the same kind of statement as a purity measured by a named laboratory for a named lot.
Is there a certificate of analysis for this Snap-8 vial?
A batch-specific Certificate of Analysis is available for this product on request. It is not published on the site yet: the batch history on the quality page lists the certificates already published, and this vial is covered by the release specification until its own is added there.
How is Snap-8 identified?
CAS 868844-74-0, molecular formula C₄₁H₇₀N₁₆O₁₆S, molecular weight 1,075.17 g/mol. Those identifiers are what an incoming-goods check compares a certificate against, and they are stated here so the comparison can be made before ordering.
How should Snap-8 be stored before reconstitution?
Store lyophilized peptide at -20°C in a dry, dark environment. Reconstitute in bacteriostatic water. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles. Lyophilized powder is stable at room temperature for shipping and short-term storage.
Where does this ship from?
British Columbia, Canada. Canadian orders are domestic, so they clear no customs and pay no import duty. International orders ship from the same facility.
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