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Ipamorelin vs Tesamorelin

Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.

Ipamorelin: DTesamorelin: A
AttributeIpamorelinTesamorelin
CategoryGrowth Hormone SecretagogueGrowth Hormone Secretagogue
Evidence RatingD — PreclinicalA — FDA Approved
Clinical StatusResearch-only / Not approved for human useFDA-approved (Egrifta SV 2019, Egrifta WR March 2025) for HIV-associated lipodystrophy
MechanismIpamorelin (sequence: Aib-His-D-2Nal-D-Phe-Lys-NH2) selectively binds to the Growth Hormone Secretagogue Receptor (GHS-R1a) on anterior pituitary somatotroph cells, increasing cAMP and activating protein kinase A to promote pulsatile GH secretion. Its structural specificity means it fits only the GH...Tesamorelin binds to and stimulates human GRF (growth hormone-releasing factor) receptors on the anterior pituitary with similar potency as endogenous GRF, stimulating synthesis and release of endogenous growth hormone. This increases IGF-1 and IGFBP-3 levels, leading to increased lipolysis and redu...
Half-Life~2 hours~26–38 minutes
BioavailabilityHigh SC bioavailability—
Molecular Weight~711.9 g/mol~5135.9 g/mol
WADA StatusProhibitedProhibited
Research Half-Life~2 hours~26–38 minutes
Key Use Cases
  • Anti-Aging
  • Body Composition
  • Sleep
  • Body Composition
Safety Concerns
  • Widely regarded as the mildest GHS available; minimal side effects in published animal and human studies
  • Common: injection site reactions (redness, swelling, bruising) in 15-30% of users, resolving within 24-48 hours
  • Common: mild temporary "head rush" or flushing immediately after injection due to sudden vasodilation
  • Common: injection site reactions (17%), arthralgia (13%), myalgia (6%), peripheral edema (6%)
  • Headache, nausea, and flu-like symptoms reported
  • May increase blood glucose -- monitoring recommended in diabetics
Contraindications
  • Active malignancy or personal/family history of cancer (GH promotes cell proliferation)
  • Pregnancy and breastfeeding
  • Pituitary disorders or prior pituitary surgery
  • Diabetes with retinopathy (GH can affect blood glucose and worsen retinopathy)
  • Pregnancy (Category X -- absolute contraindication)
  • Active cancer or history of any tumor (benign or malignant)
  • Pituitary gland disorder, tumor, or history of pituitary surgery
  • History of head injury or radiation treatment to the head
Regulatory (US)Not FDA-approved. Research chemical only. WADA-banned (S2 growth factor).FDA-approved: Egrifta SV (Oct 2019) and Egrifta WR (March 2025) for HIV-associated lipodystrophy. Prescription only.

Research Material Specifications

Catalog specifications for the corresponding research materials, including batch documentation coverage.

SpecificationIpamorelinTesamorelin
Purity Standard≥98%≥98%
CAS Number170851-70-4218949-48-5
Molecular FormulaC₃₈H₄₉N₉O₅C₂₂₃H₃₇₀N₇₂O₆₉S
Available Formats10mg, 10mg10mg
Batch COAs Published2 on file1 on file
Stock StatusIn stockIn stock

Availability at Volta Peptides

Ipamorelin 10mg

≥98% purity · HPLC verified · In stock

$49

Tesamorelin 10mg

≥98% purity · HPLC verified · In stock

$64

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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