All Comparisons
Gonadorelin vs HCG
Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.
Gonadorelin: AHCG: A
| Attribute | Gonadorelin | HCG |
|---|---|---|
| Category | Reproductive / Hormonal | Hormonal / Reproductive |
| Evidence Rating | A — FDA Approved | A — FDA Approved |
| Clinical Status | FDA-approved (Factrel for diagnostic use; Lutrepulse for pulsatile infertility treatment, now discontinued). Generic diagnostic formulation available. | FDA-approved for anovulation/infertility, hypogonadotropic hypogonadism, prepubertal cryptorchidism. |
| Mechanism | Gonadorelin binds to GnRH receptors on gonadotrope cells in the anterior pituitary gland, stimulating release of LH and FSH. When administered in a pulsatile fashion (mimicking natural hypothalamic GnRH secretion every 60–120 minutes), it maintains or restores the physiological LH/FSH surge needed f... | HCG binds to the LH/CG receptor (LHCGR) on Leydig cells and theca cells with high affinity. In males, this stimulates intratesticular testosterone production, spermatogenesis, and maintains testicular volume. In females, it triggers final oocyte maturation and ovulation. The alpha subunit is identic... |
| Half-Life | ~2–4 minutes IV; ~40 minutes SC | ~24-36 hours |
| Bioavailability | — | ~100% SC/IM |
| Molecular Weight | ~1182.4 g/mol | ~36,700 g/mol (glycoprotein) |
| WADA Status | Prohibited | Not Listed |
| Research Half-Life | ~2–4 minutes IV; ~40 minutes SC | ~24-36 hours |
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| Regulatory (US) | FDA-approved (Factrel for pituitary diagnostic testing). Lutrepulse (pulsatile pump) discontinued but was previously approved. Available through compounding pharmacies. | FDA-approved (Pregnyl, Novarel, Ovidrel). Compounding restricted since 2020 (FDA biologics reclassification). Brand products remain available. |
Research Material Specifications
Catalog specifications for the corresponding research materials, including batch documentation coverage.
| Specification | Gonadorelin | HCG |
|---|---|---|
| Purity Standard | ≥98% | ≥98% |
| CAS Number | 33515-09-2 | 9002-61-3 |
| Molecular Formula | N/A | Glycoprotein |
| Available Formats | 5mg | 5,000iu |
| Batch COAs Published | — | — |
| Stock Status | Out of stock | Out of stock |
Availability at Volta Peptides
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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