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Eledoisin: Mollusk Undecapeptide with Vasodilator Power
Eledoisin, an undecapeptide from mollusk salivary glands, acts as a potent vasodilator and smooth muscle contractor. Isolated in 1975 from Eledone species, it belongs to the tachykinin family and binds to NK-1, NK-2, and NK-3 receptors. Research highlights its potential in treating dry eyes and links to Alzheimer's progression through sequence similarity to beta-amyloid fragments.
PEGylation Shields Peptides from Immune Recognition
PEGylation covers peptide surfaces with a flexible polyethylene glycol layer that blocks immune detection. This process hides epitopes from antibodies and receptors, prevents breakdown into immunogenic fragments, and boosts hydrodynamic size to evade antigen presentation. As a result, it cuts risks of anti-drug antibodies, hypersensitivity, and clinical failures seen in early peptide drugs.