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PE-22-28 vs Semax

Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.

PE-22-28: DSemax: D
AttributePE-22-28Semax
CategoryNootropic / NeuroprotectiveNootropic / Neuroprotective
Evidence RatingD — Preclinical OnlyD — Preclinical
Clinical StatusPreclinical tool compound only. No clinical trials. No regulatory evaluation.Approved in Russia and Ukraine for stroke and cognitive disorders; not approved elsewhere
MechanismPE-22-28 blocks the TREK-1 two-pore-domain potassium channel (KCNK2/K2P2.1), which is widely expressed in the brain. TREK-1 knockout mice display a depression-resistant phenotype, suggesting that TREK-1 blockade may have antidepressant effects. PE-22-28 is a more potent and shorter analog of spadin ...Semax is a brain-selective heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro, MW ~813.88 g/mol) that crosses the blood-brain barrier via intranasal absorption. It increases brain-derived neurotrophic factor (BDNF) expression and upregulates trkB receptors, supporting neuroplasticity and long-term memory for...
Half-Life—~3–5 minutes; intranasal extends effective duration
Bioavailability——
Molecular Weight—~813.9 g/mol
WADA StatusNot ListedNot Listed
Research Half-Life—~3–5 minutes; intranasal extends effective duration
Key Use Cases
  • Antidepressant Research
  • Ion Channel Research
  • Cognitive Enhancement
Safety Concerns
  • No human safety data exist
  • Mouse studies at antidepressant-effective doses did not report overt toxicity
  • TREK-1 channels are expressed in heart, vasculature, and GI tract — potential for off-target effects
  • Generally favorable safety profile with uncommon mild side effects and no dependence potential
  • No significant hormonal effects despite ACTH-fragment origin — brain-selective mechanism reduces systemic side effects
  • Administered intranasally — mild nasal irritation possible; proper spray technique recommended
Contraindications
  • Not for human use (research compound only)
  • No established contraindications due to absence of any clinical data
  • Theoretical cardiac risk due to TREK-1 expression in cardiomyocytes
  • Pregnancy and breastfeeding (insufficient data)
  • Acute psychosis (theoretical concern regarding dopaminergic enhancement)
  • Individuals with mood disorders should use caution (dopamine effects may interact with mood conditions in complex ways)
  • Combining with other dopamine-active substances warrants caution
Regulatory (US)Not FDA-evaluated. Research tool compound. Sold by some peptide suppliers as a research chemical.Not FDA-approved. Removed from FDA Category 2 on April 15, 2026. PCAC review scheduled July 23-24, 2026. Previously classified as Category 2, prohibiting compounding. Research chemical.

Research Material Specifications

Catalog specifications for the corresponding research materials, including batch documentation coverage.

SpecificationPE-22-28Semax
Purity Standard≥98%≥98%
CAS NumberN/AN/A
Molecular FormulaN/AN/A
Available Formats10mg20mg, 10mg
Batch COAs Published——
Stock StatusOut of stockOut of stock

Availability at Volta Peptides

PE 22-28 10mg

≥98% purity · HPLC verified · Restocking

$69

Selank 10mg + Semax 10mg (20mg)

≥98% purity · HPLC verified · Restocking

$59

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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