All Comparisons
PE-22-28 vs Semax
Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.
PE-22-28: DSemax: D
| Attribute | PE-22-28 | Semax |
|---|---|---|
| Category | Nootropic / Neuroprotective | Nootropic / Neuroprotective |
| Evidence Rating | D — Preclinical Only | D — Preclinical |
| Clinical Status | Preclinical tool compound only. No clinical trials. No regulatory evaluation. | Approved in Russia and Ukraine for stroke and cognitive disorders; not approved elsewhere |
| Mechanism | PE-22-28 blocks the TREK-1 two-pore-domain potassium channel (KCNK2/K2P2.1), which is widely expressed in the brain. TREK-1 knockout mice display a depression-resistant phenotype, suggesting that TREK-1 blockade may have antidepressant effects. PE-22-28 is a more potent and shorter analog of spadin ... | Semax is a brain-selective heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro, MW ~813.88 g/mol) that crosses the blood-brain barrier via intranasal absorption. It increases brain-derived neurotrophic factor (BDNF) expression and upregulates trkB receptors, supporting neuroplasticity and long-term memory for... |
| Half-Life | Improved over spadin in rodent work; not established in humans | ~3–5 minutes; intranasal extends effective duration |
| Bioavailability | — | — |
| Molecular Weight | ~800 to 900 g/mol | ~813.9 g/mol |
| WADA Status | Not Listed | Not Listed |
| Research Half-Life | Improved over spadin in rodent work; not established in humans | ~3–5 minutes; intranasal extends effective duration |
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| Regulatory (US) | Not FDA-evaluated. Research tool compound. Sold by some peptide suppliers as a research chemical. | Not FDA-approved. Removed from FDA Category 2 on April 15, 2026. PCAC review scheduled July 23-24, 2026. Previously classified as Category 2, prohibiting compounding. Research chemical. |
Research Material Specifications
Catalog specifications for the corresponding research materials, including batch documentation coverage.
| Specification | PE-22-28 | Semax |
|---|---|---|
| Purity Standard | >99% | >99% |
| CAS Number | — | Custom Blend |
| Molecular Formula | — | Custom Blend |
| Available Formats | 10mg | 20mg, 10mg |
| Batch COAs Published | — | — |
| Stock Status | Out of stock | Out of stock |
Availability at Volta Peptides
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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