MK-677 vs Ipamorelin
Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.
| Attribute | MK-677 | Ipamorelin |
|---|---|---|
| Category | Growth Hormone Secretagogue | Growth Hormone Secretagogue |
| Evidence Rating | C — Phase I–II Clinical Trials | D — Preclinical |
| Clinical Status | Multiple Phase II trials completed. Not FDA-approved. Investigational. | Research-only / Not approved for human use |
| Mechanism | MK-677 binds to the ghrelin receptor (GHS-R1a) in the pituitary gland and hypothalamus, mimicking the hunger hormone ghrelin. This activates the GH secretagogue pathway, amplifying the natural pulsatile release of growth hormone and subsequently IGF-1, without suppressing the hypothalamic-pituitary ... | Ipamorelin (sequence: Aib-His-D-2Nal-D-Phe-Lys-NH2) selectively binds to the Growth Hormone Secretagogue Receptor (GHS-R1a) on anterior pituitary somatotroph cells, increasing cAMP and activating protein kinase A to promote pulsatile GH secretion. Its structural specificity means it fits only the GH... |
| Half-Life | ~4–6 hours (plasma); functional activity ~24 hours | ~2 hours |
| Bioavailability | Orally bioavailable | High SC bioavailability |
| Molecular Weight | ~528.7 g/mol (624.8 as mesylate salt) | ~711.9 g/mol |
| WADA Status | Prohibited | Prohibited |
| Research Half-Life | ~4–6 hours (plasma); functional activity ~24 hours | ~2 hours |
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| Regulatory (US) | Not FDA-approved. Removed from FDA Category 2 on April 15, 2026. PCAC review scheduled July 23-24, 2026. Investigational compound. Available as a research chemical. Not a controlled substance. | Not FDA-approved. Research chemical only. WADA-banned (S2 growth factor). |
Research Material Specifications
Catalog specifications for the corresponding research materials, including batch documentation coverage.
| Specification | MK-677 | Ipamorelin |
|---|---|---|
| Purity Standard | — | ≥98% |
| CAS Number | — | 170851-70-4 |
| Molecular Formula | — | C₃₈H₄₉N₉O₅ |
| Available Formats | — | 10mg, 10mg |
| Batch COAs Published | — | 2 on file |
| Stock Status | — | In stock |
Availability at Volta Peptides
MK-677
Not currently stocked at Volta Peptides.
Ipamorelin 10mg
≥98% purity · HPLC verified · In stock
$49
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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