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All Comparisons

GHRP-2 vs Ipamorelin

Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.

GHRP-2: CIpamorelin: D
AttributeGHRP-2Ipamorelin
CategoryGrowth Hormone SecretagogueGrowth Hormone Secretagogue
Evidence RatingC — Phase I–II Clinical TrialsD — Preclinical
Clinical StatusApproved in Japan for GH deficiency diagnosis; research-only elsewhereResearch-only / Not approved for human use
MechanismGHRP-2 (C45H55N9O6) binds to and activates ghrelin (GH secretagogue) receptors on pituitary somatotrophs, triggering robust pulsatile GH release. In healthy adults, 100 mcg SC daily produces acute GH stimulation. Unlike continuous GH, GHRP-2 maintains physiological feedback controls. Once-daily admi...Ipamorelin (sequence: Aib-His-D-2Nal-D-Phe-Lys-NH2) selectively binds to the Growth Hormone Secretagogue Receptor (GHS-R1a) on anterior pituitary somatotroph cells, increasing cAMP and activating protein kinase A to promote pulsatile GH secretion. Its structural specificity means it fits only the GH...
Half-Life~15–60 minutes~2 hours
Bioavailability—High SC bioavailability
Molecular Weight~817.0 g/mol~711.9 g/mol
WADA StatusProhibitedProhibited
Research Half-Life~15–60 minutes~2 hours
Key Use Cases
  • Body Composition
  • Anti-Aging
  • Body Composition
  • Sleep
Safety Concerns
  • Well tolerated in clinical trials with placebo-like safety profile at therapeutic ranges
  • May increase appetite (less than GHRP-6)
  • Can elevate cortisol and prolactin levels (less than GHRP-6)
  • Widely regarded as the mildest GHS available; minimal side effects in published animal and human studies
  • Common: injection site reactions (redness, swelling, bruising) in 15-30% of users, resolving within 24-48 hours
  • Common: mild temporary "head rush" or flushing immediately after injection due to sudden vasodilation
Contraindications
  • Active malignancy (GH/IGF-1 elevation contraindicated)
  • Pregnancy and breastfeeding
  • Pituitary disorders (outside diagnostic context)
  • Diabetes and cardiovascular conditions (GH affects glucose metabolism)
  • Active malignancy or personal/family history of cancer (GH promotes cell proliferation)
  • Pregnancy and breastfeeding
  • Pituitary disorders or prior pituitary surgery
  • Diabetes with retinopathy (GH can affect blood glucose and worsen retinopathy)
Regulatory (US)Not FDA-approved. Research chemical only. Banned by WADA.Not FDA-approved. Research chemical only. WADA-banned (S2 growth factor).

Research Material Specifications

Catalog specifications for the corresponding research materials, including batch documentation coverage.

SpecificationGHRP-2Ipamorelin
Purity Standard>99%>99%
CAS Number158861-67-7170851-70-4
Molecular FormulaC₄₅H₅₅N₉O₆C₃₈H₄₉N₉O₅
Available Formats5mg, 10mg10mg, 10mg, 5mg, 20mg, 10mg
Batch COAs Published—2 on file
Stock StatusIn stockIn stock

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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