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All Comparisons

AOD-9604 vs Tesamorelin

Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.

AOD-9604: CTesamorelin: A
AttributeAOD-9604Tesamorelin
CategoryMetabolic / Fat LossGrowth Hormone Secretagogue
Evidence RatingCPhase I–II Clinical TrialsAFDA Approved
Clinical StatusClinical development discontinued after Phase 2; GRAS status for food useFDA-approved (Egrifta SV 2019, Egrifta WR March 2025) for HIV-associated lipodystrophy
MechanismAOD-9604 (C78H123N23O23S2) works through a dual-action mechanism: it accelerates breakdown of stored fat (lipolysis) via cAMP signaling and enzymatic activation (stimulating hormone-sensitive lipase), while simultaneously blocking formation of new fat (lipogenesis). It stimulates lipolysis in a mann...Tesamorelin binds to and stimulates human GRF (growth hormone-releasing factor) receptors on the anterior pituitary with similar potency as endogenous GRF, stimulating synthesis and release of endogenous growth hormone. This increases IGF-1 and IGFBP-3 levels, leading to increased lipolysis and redu...
Half-Life~30 minutes~26–38 minutes
Bioavailability
Molecular Weight~1815.1 g/mol~5135.9 g/mol
WADA StatusProhibitedProhibited
Research Half-Life~30 minutes~26–38 minutes
Key Use Cases
  • Fat Loss
  • Body Composition
Safety Concerns
  • In extensive clinical trials, side effect profile was virtually indistinguishable from placebo
  • Mild injection site reactions (redness, pain, small welts) are the most common complaint
  • Mild headaches or flushing reported in small percentage of users
  • Common: injection site reactions (17%), arthralgia (13%), myalgia (6%), peripheral edema (6%)
  • Headache, nausea, and flu-like symptoms reported
  • May increase blood glucose -- monitoring recommended in diabetics
Contraindications
  • Active cancer (while AOD-9604 does not stimulate IGF-1, any metabolic modulator should be used with extreme caution in malignancy)
  • Pregnancy and breastfeeding (no safety data)
  • Children and adolescents (interfering with fat metabolism during puberty not recommended)
  • Pregnancy (Category X -- absolute contraindication)
  • Active cancer or history of any tumor (benign or malignant)
  • Pituitary gland disorder, tumor, or history of pituitary surgery
  • History of head injury or radiation treatment to the head
Regulatory (US)Not FDA-approved as a drug. FDA granted GRAS status for food use (2014). Available as research chemical.FDA-approved: Egrifta SV (Oct 2019) and Egrifta WR (March 2025) for HIV-associated lipodystrophy. Prescription only.

Research Material Specifications

Catalog specifications for the corresponding research materials, including batch documentation coverage.

SpecificationAOD-9604Tesamorelin
Purity Standard≥98%≥98%
CAS Number221231-10-3218949-48-5
Molecular FormulaN/AC₂₂₃H₃₇₀N₇₂O₆₉S
Available Formats10mg10mg, 20mg, 10mg
Batch COAs Published
Stock StatusOut of stockIn stock

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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