pramlintide

Amylins (IAPP): Structure, Receptors, and Key Analogues

Amylin, or islet amyloid polypeptide (IAPP), is a 37-amino-acid peptide co-produced with insulin in pancreatic β-cells at ratios from 1:10 to 1:100. It slows gastric emptying, suppresses glucagon secretion after meals, and promotes satiety through brainstem pathways. Synthetic versions like pramlintide and cagrilintide show promise in managing postprandial glucose and obesity, with clinical trials demonstrating significant weight loss.