All Comparisons
Retatrutide vs Survodutide
Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.
Retatrutide: BSurvodutide: B
| Attribute | Retatrutide | Survodutide |
|---|---|---|
| Category | Metabolic / Triple Agonist | Metabolic / Dual Agonist |
| Evidence Rating | B — Phase III / NDA Filed | B — Phase III / NDA Filed |
| Clinical Status | Phase 3 clinical trials (Eli Lilly TRIUMPH program) | Phase 3 clinical trials for MASH and obesity (Boehringer Ingelheim) |
| Mechanism | Retatrutide simultaneously activates three receptors: GLP-1 (reduces appetite, slows gastric emptying, improves insulin secretion), GIP (enhances insulin sensitivity, glucose control), and glucagon (increases energy expenditure, fat oxidation, thermogenesis). This triple synergy combines reduced cal... | Survodutide simultaneously activates glucagon receptors (increasing hepatic fat oxidation, energy expenditure, and thermogenesis) and GLP-1 receptors (reducing appetite, slowing gastric emptying, improving insulin secretion). The glucagon component specifically drives hepatic lipid mobilization — bu... |
| Half-Life | ~6 days (allows once-weekly dosing) | ~5-6 days (allows once-weekly dosing) |
| Bioavailability | SC injection | — |
| Molecular Weight | — | — |
| WADA Status | Not Prohibited | Not Listed |
| Research Half-Life | ~6 days (allows once-weekly dosing) | ~5-6 days (allows once-weekly dosing) |
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| Regulatory (US) | Not FDA-approved. Phase 3 TRIUMPH program ongoing (Eli Lilly). TRIUMPH-4 reported 28.7% body weight loss at 12 mg over 68 weeks. Seven Phase 3 readouts expected in 2026. Regulatory submission expected 2026; approval anticipated 2027-2028. | Not FDA-approved. Phase 3 trials ongoing for MASH and obesity. Breakthrough therapy designation for MASH. |
Research Material Specifications
Catalog specifications for the corresponding research materials, including batch documentation coverage.
| Specification | Retatrutide | Survodutide |
|---|---|---|
| Purity Standard | >99% | >99% |
| CAS Number | 2381089-83-2 | — |
| Molecular Formula | C₂₂₁H₃₄₂N₄₆O₆₈ | — |
| Available Formats | 20mg, 10mg, 5mg, 30mg | 10mg |
| Batch COAs Published | 1 on file | — |
| Stock Status | In stock | Out of stock |
Availability at Volta Peptides
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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