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PT-141 vs Kisspeptin

Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.

PT-141: AKisspeptin: C
AttributePT-141Kisspeptin
CategorySexual HealthReproductive / Hormonal
Evidence RatingA — FDA ApprovedC — Phase I–II Clinical Trials
Clinical StatusFDA-approved (Vyleesi for HSDD in premenopausal women)Investigational / Active clinical trials in reproductive medicine
MechanismPT-141 (MW ~1025 g/mol, C50H68N14O10, half-life 2-6 hours) is a synthetic analog of alpha-MSH targeting MC3R and MC4R. MC4R activation in the CNS enhances dopamine release in the nucleus accumbens and medial preoptic area, increasing sexual motivation. Subcutaneous bioavailability is approximately 1...Kisspeptin binds to GPR54 (KISS1R) on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This drives LH and FSH secretion from the pituitary, which increases endogenous testosterone/estrogen production. Kisspeptin works through the natural HPG axis cascade without suppressing it (u...
Half-Life~2.5 hoursKisspeptin-54: ~28 minutes IV; KP-10: ~4 minutes
Bioavailability~25% SC—
Molecular Weight~1025.2 g/molKisspeptin-54: ~5862 g/mol; KP-10: ~1302 g/mol
WADA StatusNot ListedNot Listed
Research Half-Life~2.5 hoursKisspeptin-54: ~28 minutes IV; KP-10: ~4 minutes
Key Use Cases
  • Sexual Health
  • Reproductive Health
Safety Concerns
  • Common: nausea (~40%, most common and dose-limiting), flushing (50-70%), headache (10-25%), injection site reactions
  • Transient increases in blood pressure and heart rate; not recommended for uncontrolled hypertension or cardiovascular disease
  • Skin hyperpigmentation with repeated use (MC1R agonism); darker-skinned patients more susceptible; resolution not confirmed in all patients
  • Generally well-tolerated in clinical trials at studied doses
  • Short-acting -- effects are transient
  • Continuous administration may cause desensitization/tachyphylaxis of the reproductive axis
Contraindications
  • Uncontrolled hypertension or cardiovascular disease
  • Concurrent use with naltrexone
  • History of melanoma (caution due to melanocortin receptor activation)
  • Pregnancy and breastfeeding
  • Pregnancy (potential to disrupt hormonal balance)
  • Hormone-sensitive cancers (breast, prostate, ovarian)
  • Conditions where gonadotropin stimulation is contraindicated
  • Central precocious puberty (kisspeptin system already overactive)
Regulatory (US)FDA-approved (Vyleesi, 2019) for HSDD in premenopausal women. 1.75 mg SC on-demand, max 8 doses/month.Not FDA-approved. Investigational use in clinical trials. WADA-prohibited.

Research Material Specifications

Catalog specifications for the corresponding research materials, including batch documentation coverage.

SpecificationPT-141Kisspeptin
Purity Standard≥98%≥98%
CAS Number189691-06-3N/A
Molecular FormulaN/AN/A
Available Formats10mg10mg
Batch COAs Published——
Stock StatusOut of stockOut of stock

Availability at Volta Peptides

PT-141 10mg

≥98% purity · HPLC verified · Restocking

$31.79

Kisspeptin-10 10mg

≥98% purity · HPLC verified · Restocking

$28.18

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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