All Comparisons
IGF-1 vs IGF-1 LR3
Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.
IGF-1: AIGF-1 LR3: D
| Attribute | IGF-1 | IGF-1 LR3 |
|---|---|---|
| Category | Growth Factor | Growth Factor |
| Evidence Rating | A — FDA Approved | D — Preclinical |
| Clinical Status | FDA-approved (Increlex/mecasermin) for severe primary IGF-1 deficiency. | No clinical trials for therapeutic use. Research compound only. |
| Mechanism | IGF-1 binds to the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase that activates the PI3K/Akt pathway (promoting cell survival and protein synthesis) and the MAPK/ERK pathway (promoting cell proliferation). In circulation, 95-99% of IGF-1 is bound to IGF binding proteins, primarily IGFBP-3 in a... | IGF-1 LR3 binds to IGF-1 receptors on target cells with high affinity, initiating tyrosine kinase signaling that activates the PI3K/Akt/mTOR pathway, increasing protein synthesis, glucose uptake, and cellular survival while inhibiting muscle protein breakdown (anti-catabolic). Its low affinity for I... |
| Half-Life | ~10-15 min (free); ~12-15 hours (bound to IGFBP-3/ALS complex) | 20-30 hours |
| Bioavailability | ~100% (subcutaneous) | — |
| Molecular Weight | ~7649 g/mol | ~9,111 g/mol (9.1 kDa) |
| WADA Status | Prohibited | Prohibited |
| Research Half-Life | ~10-15 min (free); ~12-15 hours (bound to IGFBP-3/ALS complex) | 20-30 hours |
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| Regulatory (US) | FDA-approved (Increlex, mecasermin) for severe primary IGF-1 deficiency. WADA-banned. | Not FDA-approved. Research chemical only. WADA-banned (S2 growth factors). |
Research Material Specifications
Catalog specifications for the corresponding research materials, including batch documentation coverage.
| Specification | IGF-1 | IGF-1 LR3 |
|---|---|---|
| Purity Standard | ≥98% | ≥98% |
| CAS Number | N/A | N/A |
| Molecular Formula | N/A | N/A |
| Available Formats | 1mg | 1mg |
| Batch COAs Published | — | — |
| Stock Status | Out of stock | Out of stock |
Availability at Volta Peptides
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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