All Comparisons
Hexarelin vs Sermorelin
Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.
Hexarelin: CSermorelin: C
| Attribute | Hexarelin | Sermorelin |
|---|---|---|
| Category | Growth Hormone Secretagogue | Growth Hormone Secretagogue |
| Evidence Rating | C — Phase I–II Clinical Trials | C — Phase I–II Clinical Trials |
| Clinical Status | Phase II completed. Development discontinued due to tolerance/desensitization concerns. | Previously FDA-approved (Geref, discontinued); now used off-label via compounding |
| Mechanism | Hexarelin binds to and activates the ghrelin/growth hormone secretagogue receptor (GHS-R1a) in the pituitary and hypothalamus through a triple mechanism: direct stimulation of pituitary somatotroph cells to release stored GH, stimulation of hypothalamic GHRH-releasing neurons, and suppression of som... | Sermorelin binds to GHRH receptors (GHRHR) on somatotroph cells in the anterior pituitary gland, stimulating both transcription of the HGH gene and pulsatile release of endogenous growth hormone. The released HGH increases protein synthesis, fat breakdown (lipolysis), and tissue repair across multip... |
| Half-Life | ~70 minutes | ~10–20 minutes |
| Bioavailability | — | — |
| Molecular Weight | ~887 g/mol | ~3357.9 g/mol |
| WADA Status | Prohibited | Prohibited |
| Research Half-Life | ~70 minutes | ~10–20 minutes |
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| Regulatory (US) | Not FDA-approved. Development discontinued. Research chemical only. | Previously FDA-approved (Geref) for pediatric GH deficiency; voluntarily discontinued by manufacturer for commercial reasons. FDA confirmed in 2013 it was not withdrawn for safety. Available via compounding pharmacies. WADA-banned. |
Research Material Specifications
Catalog specifications for the corresponding research materials, including batch documentation coverage.
| Specification | Hexarelin | Sermorelin |
|---|---|---|
| Purity Standard | ≥98% | ≥98% |
| CAS Number | 140703-51-1 | 86168-78-7 |
| Molecular Formula | N/A | C₁₄₉H₂₄₆N₄₄O₄₂S |
| Available Formats | 5mg | 5mg |
| Batch COAs Published | — | 1 on file |
| Stock Status | Out of stock | In stock |
Availability at Volta Peptides
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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