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Gonadorelin vs Oxytocin

Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.

Gonadorelin: AOxytocin: A
AttributeGonadorelinOxytocin
CategoryReproductive / HormonalReproductive / Hormonal
Evidence RatingAFDA ApprovedAApproved Medication with Strong Human Data
Clinical StatusFDA-approved (Factrel for diagnostic use; Lutrepulse for pulsatile infertility treatment, now discontinued). Generic diagnostic formulation available.FDA-approved (Pitocin for labor induction, augmentation of labor, and postpartum hemorrhage)
MechanismGonadorelin binds to GnRH receptors on gonadotrope cells in the anterior pituitary gland, stimulating release of LH and FSH. When administered in a pulsatile fashion (mimicking natural hypothalamic GnRH secretion every 60–120 minutes), it maintains or restores the physiological LH/FSH surge needed f...Oxytocin binds to the oxytocin receptor (OXTR), a Gq/11-coupled GPCR expressed in uterine myometrium, mammary tissue, and the central nervous system. Receptor activation triggers phospholipase C-mediated hydrolysis of PIP2 to IP3 and DAG, causing intracellular calcium release from the sarcoplasmic r...
Half-Life~2–4 minutes IV; ~40 minutes SC~1-6 minutes (IV)
Bioavailability~2-5% intranasal
Molecular Weight~1182.4 g/mol~1007.2 g/mol
WADA StatusProhibitedNot Listed
Research Half-Life~2–4 minutes IV; ~40 minutes SC~1-6 minutes (IV)
Key Use Cases
  • Reproductive Health
  • Reproductive Health
Safety Concerns
  • Common: headache, flushing, nausea, dizziness, injection site reactions
  • Rare: facial/lip/tongue/throat swelling (allergic reaction)
  • Injection site hardening with repeated SC administration
  • Uterine hyperstimulation/tachysystole: can cause excessive contractions leading to fetal distress; requires continuous fetal monitoring
  • Water intoxication and hyponatremia: oxytocin has antidiuretic properties at high doses; risk increases with prolonged infusion and hypotonic IV fluids
  • Uterine rupture: rare but life-threatening, especially in patients with prior uterine surgery
Contraindications
  • Hormone-sensitive cancers (breast, prostate) — may initially stimulate tumor growth
  • Pituitary apoplexy risk in patients with pituitary adenomas
  • Pregnancy (Category X)
  • Concurrent use with androgens, estrogens, progestins, or glucocorticoids may affect response
  • Significant cephalopelvic disproportion or unfavorable fetal position
  • Placenta previa or vasa previa
  • Prior classical (vertical) cesarean section or major uterine surgery
  • Active genital herpes infection
Regulatory (US)FDA-approved (Factrel for pituitary diagnostic testing). Lutrepulse (pulsatile pump) discontinued but was previously approved. Available through compounding pharmacies.FDA-approved (Pitocin). Used for labor induction, augmentation, and postpartum hemorrhage management.

Research Material Specifications

Catalog specifications for the corresponding research materials, including batch documentation coverage.

SpecificationGonadorelinOxytocin
Purity Standard≥98%≥98%
CAS Number33515-09-250-56-6
Molecular FormulaN/AC₄₃H₆₆N₁₂O₁₂S₂
Available Formats5mg10mg
Batch COAs Published
Stock StatusOut of stockOut of stock

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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