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Epithalon vs NAD+ (Nicotinamide Adenine Dinucleotide)

Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.

Epithalon: DNAD+ (Nicotinamide Adenine Dinucleotide): C
AttributeEpithalonNAD+ (Nicotinamide Adenine Dinucleotide)
CategoryAnti-Aging / TelomereAnti-Aging / Telomere
Evidence RatingD — PreclinicalC — Early Human / Mixed Evidence
Clinical StatusResearch-only / No approved human indication in Western countriesNAD+ IV: used clinically at anti-aging and addiction clinics; no FDA approval. NMN: Phase I/II human trials completed (Yoshino et al., Science 2021). NR: multiple human trials completed.
MechanismEpithalon (C14H22N4O9, MW ~390 daltons) activates telomerase, particularly the catalytic subunit TERT (telomerase reverse transcriptase), extending telomeres at chromosome ends. Its small size allows blood-brain barrier penetration and broad tissue distribution, though oral bioavailability is limite...Functions as: (1) an electron carrier in glycolysis, TCA cycle, and oxidative phosphorylation; (2) a substrate for sirtuins (SIRT1-7), which regulate gene expression, DNA repair, and metabolism; (3) a substrate for PARPs, which repair DNA damage; (4) a substrate for CD38/CD157, involved in calcium s...
Half-LifeSeveral hours~30 minutes (IV plasma); intracellular NAD+ turnover ~6-10 hours
Bioavailability—~100% IV; oral NAD+ <5%; NMN and NR are oral precursors
Molecular Weight~390.3 g/mol663.43 g/mol
WADA StatusNot ListedNot Prohibited
Research Half-LifeSeveral hours~30 minutes (IV plasma); intracellular NAD+ turnover ~6-10 hours
Key Use Cases
  • Anti-Aging
  • Anti-Aging & Longevity
  • Metabolic Health
Safety Concerns
  • Generally well tolerated; no serious adverse events reported in decades of Russian clinical use
  • Good safety margin: doses studied range from 0.5 to 5 mg with no dose-limiting toxicity reported
  • Mild headaches, dizziness, and GI discomfort possible
  • IV NAD+: commonly causes flushing, nausea, chest tightness, abdominal cramping during infusion — dose-rate dependent
  • Rare tachycardia and blood pressure changes during IV infusion
  • Oral NMN and NR are generally well-tolerated at doses up to 1200mg/day
Contraindications
  • Active cancer or history of cancer (theoretical concern with telomerase activation, despite lack of evidence for increased risk)
  • Pregnancy and breastfeeding (no safety data)
  • Autoimmune conditions (unknown interaction)
  • Active or suspected cancer (theoretical risk of fueling tumor metabolism)
  • Pregnancy or breastfeeding
  • History of cardiac arrhythmias (IV NAD+ can affect heart rate)
  • Caution with blood pressure medications (IV NAD+ may cause hypotension)
Regulatory (US)Not FDA-approved. Removed from FDA Category 2 on April 15, 2026. PCAC review scheduled July 23-24, 2026. Previously classified as Category 2, prohibiting compounding. Research chemical.—

Research Material Specifications

Catalog specifications for the corresponding research materials, including batch documentation coverage.

SpecificationEpithalonNAD+ (Nicotinamide Adenine Dinucleotide)
Purity Standard≥98%≥98%
CAS Number307297-39-8N/A
Molecular FormulaN/AC₂₁H₂₇N₇O₁₄P₂
Available Formats50mg1,000mg
Batch COAs Published——
Stock StatusOut of stockOut of stock

Availability at Volta Peptides

Epithalon 50mg

≥98% purity · HPLC verified · Restocking

$139

NAD+ 1000mg

≥98% purity · HPLC verified · Restocking

$119

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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