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All Comparisons

5-Amino-1MQ vs AOD-9604

Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.

5-Amino-1MQ: DAOD-9604: C
Attribute5-Amino-1MQAOD-9604
CategoryMetabolic / Fat LossMetabolic / Fat Loss
Evidence RatingDAnimal/Preclinical OnlyCPhase I–II Clinical Trials
Clinical StatusPreclinical only. No IND filed. No human clinical trials registered as of 2026.Clinical development discontinued after Phase 2; GRAS status for food use
MechanismSelectively inhibits NNMT, an enzyme highly expressed in white adipose tissue that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor. NNMT inhibition increases intracellular NAD+ and SAM concentrations. In diet-induced obese mice, NNMT inhibitors reduced bo...AOD-9604 (C78H123N23O23S2) works through a dual-action mechanism: it accelerates breakdown of stored fat (lipolysis) via cAMP signaling and enzymatic activation (stimulating hormone-sensitive lipase), while simultaneously blocking formation of new fat (lipogenesis). It stimulates lipolysis in a mann...
Half-LifeUnknown in humans; estimated hours based on animal PK~30 minutes
BioavailabilityOral bioavailability demonstrated in mice
Molecular Weight~173.21 g/mol~1815.1 g/mol
WADA StatusNot ListedProhibited
Research Half-LifeUnknown in humans; estimated hours based on animal PK~30 minutes
Key Use Cases
  • Weight Management
  • Fat Loss
Safety Concerns
  • No human safety data available
  • In mouse studies, no obvious toxicity at effective doses over 10-day treatment periods
  • Does not cross the blood-brain barrier in animal models
  • In extensive clinical trials, side effect profile was virtually indistinguishable from placebo
  • Mild injection site reactions (redness, pain, small welts) are the most common complaint
  • Mild headaches or flushing reported in small percentage of users
Contraindications
  • No established contraindications due to lack of human data
  • Theoretical concern with medications metabolized via methylation pathways
  • Should not be used by pregnant or breastfeeding women
  • Active cancer (while AOD-9604 does not stimulate IGF-1, any metabolic modulator should be used with extreme caution in malignancy)
  • Pregnancy and breastfeeding (no safety data)
  • Children and adolescents (interfering with fat metabolism during puberty not recommended)
Regulatory (US)Not FDA-approved as a drug. FDA granted GRAS status for food use (2014). Available as research chemical.

Research Material Specifications

Catalog specifications for the corresponding research materials, including batch documentation coverage.

Specification5-Amino-1MQAOD-9604
Purity Standard≥98%≥98%
CAS NumberN/A221231-10-3
Molecular FormulaC₁₀H₁₂N₂ON/A
Available Formats10mg10mg
Batch COAs Published
Stock StatusOut of stockOut of stock

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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