peptide-discovery
2 articles tagged with ‘peptide-discovery’
DNA-Encoded Libraries Enable Tunable Cyclic Peptide Discovery
Researchers led by Petrov et al. in Nature Communications developed a dual-display ESAC library that provides three levels of conformational restraint in cyclic peptides: open, semi-closed, and fully closed. This 56 million-member library addresses purity and diversity issues in conventional DNA-encoded libraries. Selections against thrombin, streptavidin, and PLAP revealed target-specific preferences for peptide flexibility, guiding future designs.
Peptide Drug Discovery: From Concept to Candidate
Peptide drug discovery integrates design, synthesis, and analytics to advance programs from early ideas to lead candidates. This approach addresses challenges where small molecules fall short, such as broad protein-protein interaction interfaces. Services cover hit identification, optimization for stability and potency, analytical verification, and scale-up for preclinical studies, supporting fields like metabolic disease and oncology.