incretin
3 articles tagged with ‘incretin’
Tirzepatide vs Retatrutide: Evidence, Mechanisms, Safety
This reference distinguishes randomized trial evidence from extrapolation for tirzepatide and retatrutide, clarifying mechanisms and safety. It highlights the absence of direct head-to-head trials and the limits of current data.
Semaglutide vs Tirzepatide vs Retatrutide: A Research Comparison of GLP-1 Receptor Agonist Peptides
An evidence-based comparison of three incretin-based research peptides — semaglutide (GLP-1), tirzepatide (GIP/GLP-1), and retatrutide (GIP/GLP-1/glucagon) — covering receptor pharmacology, clinical trial data from the STEP, SURMOUNT, and Phase 2 retatrutide programs, stability considerations, and analytical quality benchmarks.
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GLP-1 (7-36) Amide: Incretin Hormone Structure and Role
GLP-1 (7-36) amide serves as a key incretin hormone derived from proglucagon in the gut, stimulating insulin secretion in a glucose-dependent manner. It circulates mainly post-meals at levels peaking at 30-60 pM, but degrades rapidly via DPP-4 with a half-life under 2 minutes. Research highlights its potential for type II diabetes treatment despite stability challenges.