fmoc/tbu

Peptide Synthesis: SPPS Strategies and Peptidomimetics Guide

Solid phase peptide synthesis, pioneered by Bruce Merrifield, revolutionized peptide production by simplifying purification and enabling automation. Key strategies include Boc/Bzl and Fmoc/tBu approaches, each with distinct protecting group mechanisms. Peptidomimetics address drug design challenges like degradation and poor absorption through non-peptidic mimics of peptide structures.