drug-delivery
3 articles tagged with ‘drug-delivery’
Cell-Penetrating Peptides Aid Intracellular Delivery
Over the last decade, researchers have studied cell-penetrating peptides for delivering cargoes across cell membranes. These peptides carry low molecular weight drugs, imaging agents, peptides, oligonucleotides, proteins, and carriers like liposomes and polymeric nanoparticles. Their non-toxic membrane crossing boosts drug bioavailability, though uptake mechanisms remain unclear.
Self-Assembling Peptides: Mechanisms and Biomedical Applications
Self-assembling peptides form structured nanoscale formations through non-covalent forces like hydrogen bonding, electrostatic interactions, hydrophobic effects, and π-π stacking. These peptides enable applications in drug delivery, tissue engineering, and biosensors by creating nanofibers, nanoparticles, and hydrogels. Factors such as pH, temperature, and amino acid sequences control their assembly and functionality.
Peptide Linkers: Vital Connectors in Biotech and Drug Design
Peptide linkers join proteins, antibodies, and drugs to enable targeted therapies like antibody-drug conjugates. They come in flexible, rigid, cleavable, and non-cleavable forms, with designs tailored by length and amino acid choice for stability and function. Applications span cancer treatments, fusion proteins, and vaccine development, optimizing delivery and reducing side effects.