drug development
2 articles tagged with ‘drug development’
Broad Opportunities in Polypeptide Drug Development
More than 7,000 natural polypeptides have been identified, playing roles in human physiology such as hormones and neurotransmitters. Therapeutic polypeptides are seeing renewed commercial interest after wide use in pharmaceuticals over the past decade. Advances in multifunctional peptides like GLP-1 agonists and cell-penetrating technologies promise expanded applications despite challenges.
Key Strategies in Cyclic Peptide Drug Development
Cyclic peptides provide strong target affinity and conformational control, yet development often faces hurdles like permeability issues and metabolic instability. This article outlines modular support from design review to preclinical preparation, including scaffold optimization, synthesis via solid-phase peptide synthesis (SPPS), SAR expansion, and developability assessments. Teams can align workflows to specific stages, such as hit generation or lead refinement, to address common risks effectively.