cyclic peptides
3 articles tagged with ‘cyclic peptides’
Advanced Cyclic Peptide Synthesis in Drug Discovery
Natural cyclic peptides offer unique structures and potent biological effects, with over forty approved for clinical use in antibiotics, anticancer agents, immunomodulators, and anti-inflammatory drugs. Synthesis faces challenges from structural complexity and scalability needs. Recent studies since 2017 highlight evolving strategies like head-to-tail and side-chain linkages to improve efficiency.
Key Strategies in Cyclic Peptide Drug Development
Cyclic peptides provide strong target affinity and conformational control, yet development often faces hurdles like permeability issues and metabolic instability. This article outlines modular support from design review to preclinical preparation, including scaffold optimization, synthesis via solid-phase peptide synthesis (SPPS), SAR expansion, and developability assessments. Teams can align workflows to specific stages, such as hit generation or lead refinement, to address common risks effectively.
Cyclic Peptides from Pseudostellaria heterophylla: Design to Scale-Up
Cyclic peptides from the traditional Chinese herb Pseudostellaria heterophylla, or Tai-Zi-Shen, show promise in drug discovery due to their stability and activities like anti-cancer and anti-inflammatory effects. Researchers have isolated 19 such peptides, with heterophyllin A and B standing out for metabolic stability and selectivity. Advances in chemical synthesis and biotechnology aim to move these compounds from lab to industrial production.