cns delivery

Peptides Targeting BBB for CNS Drug Delivery Advances

Peptides serve as targeted carriers to transport therapeutics across the blood-brain barrier via receptor-mediated transcytosis, bypassing invasive methods. They mimic natural ligands to engage receptors like transferrin and LRP1 on brain endothelial cells. Challenges include balancing affinity, stability, and release to avoid saturation and ensure brain entry without toxicity.