b lymphocytes

Epstein-Barr Virus: Biology, Entry, and Early Infection Mechanisms

Epstein-Barr virus (EBV), first identified in 1964 in Burkitt's lymphoma, is a human herpesvirus that establishes lifelong persistence in memory B cells. This article covers EBV's virion structure, cell entry pathways into epithelial cells and B lymphocytes, and the pre-latent phase where viral gene expression begins to reprogram host cells for survival.