antimicrobial-peptides
3 articles tagged with ‘antimicrobial-peptides’
Peptide Drugs Target Prostate Cancer, Viruses, and Brain Injuries
Recent research highlights peptides as promising drugs due to their high affinity, selectivity, low toxicity, and simple synthesis. Advances include peptidomimetics that attack prostate tumors with TMPRSS2-ERG fusion, stem-derived peptides blocking Japanese encephalitis and Zika viruses, an engineered antimicrobial peptide effective against resistant bacteria, and a four-amino-acid sequence that targets injured brain tissue. These developments suggest peptides could address multiple serious conditions.
Cyclo-zp80r Boosts NFC Orange Juice Preservation
A study in Foods shows the cyclic peptide cyclo-zp80r effectively combats Salmonella enterica and Listeria monocytogenes in NFC orange juice, reducing S. enterica counts by 3.6 Log CFU/mL in one day. It outperforms nisin, raises Galleria mellonella larvae survival from 0% to 40%, and remains stable at 121°C. Mechanisms include membrane disruption, ROS production, and DNA binding, though production faces purification challenges.
Antimicrobial Peptides: Structures, Mechanisms, and Research Roles
Antimicrobial peptides offer promise against antibiotic-resistant pathogens through membrane disruption and intracellular actions. They target bacteria, fungi, viruses, and even biofilms, while modulating immune responses and aiding wound healing. Research highlights their structural diversity and selective toxicity, positioning them as alternatives to traditional antibiotics.