How is gonadorelin different from HCG?

Gonadorelin stimulates your pituitary to produce LH naturally, while HCG mimics LH directly. Gonadorelin works "upstream" — it preserves the full hypothalamic-pituitary-gonadal axis. HCG bypasses the pituitary entirely. Both can maintain testicular function during TRT.

Why is gonadorelin replacing HCG at some clinics?

After the FDA reclassified HCG as a biologic in 2020, compounding pharmacies could no longer easily produce it. Some TRT clinics switched to gonadorelin as an alternative to maintain fertility and testicular size during testosterone therapy.

Does continuous gonadorelin increase or decrease testosterone?

Pulsatile administration (every 60–120 min) increases LH/FSH and thus testosterone. But continuous (non-pulsatile) administration paradoxically suppresses LH/FSH by downregulating GnRH receptors — this is the same mechanism used in prostate cancer treatment with GnRH agonists.

What is the recommended dose range for Gonadorelin?

The research dose range is Diagnostic: 100 mcg IV/SC single dose; TRT support: 50–100 mcg SC 2x daily, administered via Subcutaneous or Intravenous, Diagnostic: single dose; TRT support: 2x daily or pulsatile.

peptide dosing

Gonadorelin Dosing & Reconstitution Guide

Complete dosing reference for Gonadorelin (Reproductive / Hormonal). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Subcutaneous or Intravenous Frequency: Diagnostic: single dose; TRT support: 2x daily or pulsatile Dose Range: Diagnostic: 100 mcg IV/SC single dose; TRT support: 50–100 mcg SC 2x daily Cycle Length: Diagnostic: single use; TRT support: ongoing concurrent with testosterone Timing: Diagnostic: morning (fasting preferred). For females: test in early follicular phase (Days 1–7)

Reconstitution

Vial Size: 2mg Water Volume: 2mL Concentration: 1mg/mL

Storage

Lyophilized: −20 °C (−4 °F) Reconstituted: Use within 1 day of reconstitution per labeling Shelf Life: 1 days

Injection Sites

Abdomen, Upper arm

Safety & Contraindications

Safety: Common: headache, flushing, nausea, dizziness, injection site reactions Rare: facial/lip/tongue/throat swelling (allergic reaction) Injection site hardening with repeated SC administration

Contraindications: Hormone-sensitive cancers (breast, prostate) — may initially stimulate tumor growth; Pituitary apoplexy risk in patients with pituitary adenomas; Pregnancy (Category X)

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Gonadorelin Dosing Guide Peptides for Reproductive Health

Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.