Why is bradykinin important in medicine?

Bradykinin is clinically relevant as the mediator of ACE inhibitor-associated cough and angioedema, the central pathogenic molecule in hereditary angioedema (HAE), and an important pain and inflammation mediator. Drugs targeting the bradykinin pathway (icatibant, ecallantide, lanadelumab) are approved for HAE treatment.

What is the connection between bradykinin and ACE inhibitors?

ACE (angiotensin-converting enzyme) is also known as kininase II, the primary enzyme that degrades bradykinin. ACE inhibitors block this degradation, leading to elevated bradykinin levels. This causes the characteristic dry cough in 5-35% of patients and rarely angioedema. The bradykinin pathway may also contribute to ACE inhibitors' cardioprotective effects.

Is bradykinin used as a drug?

No. Bradykinin is too potent, non-selective, and rapidly degraded (half-life ~15-30 seconds) to be useful as a therapeutic agent. Instead, drugs targeting the bradykinin system include B2 receptor antagonists (icatibant) for HAE and kallikrein inhibitors (lanadelumab) to prevent bradykinin generation.

What is the recommended dose range for Bradykinin?

The research dose range is 100–500 ng/kg/min in human provocation studies, administered via Intravenous infusion (research only), Single-dose or short-duration infusion.

peptide dosing

Bradykinin Dosing & Reconstitution Guide

Complete dosing reference for Bradykinin (Cardiovascular / Vasoactive). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Intravenous infusion (research only) Frequency: Single-dose or short-duration infusion Dose Range: 100–500 ng/kg/min in human provocation studies

Safety & Contraindications

Safety: Not used as an exogenous therapeutic agent Endogenous bradykinin excess causes angioedema, hypotension, and pain Bradykinin accumulation is the mechanism of ACE inhibitor cough (5-35% of patients) and angioedema (0.1-0.7%)

Contraindications: Not applicable as a therapeutic agent; Conditions with excess bradykinin activity (hereditary angioedema, ACE inhibitor angioedema) are treated with bradykinin pathway antagonists

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Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.