All Comparisons
PE-22-28 vs Pinealon
Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.
PE-22-28: DPinealon: D
| Attribute | PE-22-28 | Pinealon |
|---|---|---|
| Category | Nootropic / Neuroprotective | Nootropic / Neuroprotective |
| Evidence Rating | D — Preclinical Only | D — Preclinical / Uncontrolled Russian Studies |
| Clinical Status | Preclinical tool compound only. No clinical trials. No regulatory evaluation. | Preclinical / small open-label Russian studies only. No controlled clinical trials. Sold as a dietary supplement in Russia. |
| Mechanism | PE-22-28 blocks the TREK-1 two-pore-domain potassium channel (KCNK2/K2P2.1), which is widely expressed in the brain. TREK-1 knockout mice display a depression-resistant phenotype, suggesting that TREK-1 blockade may have antidepressant effects. PE-22-28 is a more potent and shorter analog of spadin ... | According to the Khavinson bioregulatory peptide theory, pinealon is proposed to penetrate cell membranes, enter the nucleus, and interact with specific DNA sequences to regulate gene expression related to neuronal function and pineal melatonin synthesis. Preclinical studies from the Khavinson group... |
| Half-Life | — | — |
| Bioavailability | — | — |
| Molecular Weight | — | ~418 g/mol |
| WADA Status | Not Listed | Not Listed |
| Research Half-Life | — | — |
| Key Use Cases |
|
|
| Safety Concerns |
|
|
| Contraindications |
|
|
| Regulatory (US) | Not FDA-evaluated. Research tool compound. Sold by some peptide suppliers as a research chemical. | Not FDA-approved or evaluated. Not available as a pharmaceutical. Occasionally sold online as a research peptide. |
Research Material Specifications
Catalog specifications for the corresponding research materials, including batch documentation coverage.
| Specification | PE-22-28 | Pinealon |
|---|---|---|
| Purity Standard | ≥98% | ≥98% |
| CAS Number | N/A | N/A |
| Molecular Formula | N/A | N/A |
| Available Formats | 10mg | 10mg |
| Batch COAs Published | — | — |
| Stock Status | Out of stock | Out of stock |
Availability at Volta Peptides
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
Explore More
Comparisons
Compare any two peptides side-by-side or browse our curated popular matchups.