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GHRP-6 vs Hexarelin

Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.

GHRP-6: DHexarelin: C
AttributeGHRP-6Hexarelin
CategoryGrowth Hormone SecretagogueGrowth Hormone Secretagogue
Evidence RatingDPreclinicalCPhase I–II Clinical Trials
Clinical StatusResearch-only / Not approved for human usePhase II completed. Development discontinued due to tolerance/desensitization concerns.
MechanismGHRP-6 functions as a synthetic ghrelin mimetic by binding to GHS-R1a in the pituitary and hypothalamus, triggering pulsatile GH release and raising IGF-1 levels. Unlike continuous GH administration, GHRP-6 maintains physiological feedback: as GH and IGF-1 rise, endogenous somatostatin increases to ...Hexarelin binds to and activates the ghrelin/growth hormone secretagogue receptor (GHS-R1a) in the pituitary and hypothalamus through a triple mechanism: direct stimulation of pituitary somatotroph cells to release stored GH, stimulation of hypothalamic GHRH-releasing neurons, and suppression of som...
Half-Life~15–60 minutes~70 minutes
Bioavailability
Molecular Weight~873.0 g/mol~887 g/mol
WADA StatusProhibitedProhibited
Research Half-Life~15–60 minutes~70 minutes
Key Use Cases
  • Body Composition
  • Body Composition
  • Anti-Aging
Safety Concerns
  • Intense hunger due to ghrelin receptor activation (more pronounced than other GH secretagogues)
  • Transient mild increases in cortisol and ACTH (typically not clinically significant)
  • Water retention and bloating reported
  • Generally well-tolerated in clinical trials
  • Transient cortisol and prolactin elevation at higher doses
  • Hunger increase (ghrelin receptor activation)
Contraindications
  • Active malignancy (GH/IGF-1 elevation contraindicated)
  • Pregnancy and breastfeeding
  • Pituitary disorders
  • Conditions worsened by increased appetite, cortisol, or fluid retention
  • Active cancer (GH/IGF-1 axis stimulation)
  • Pituitary tumors
  • Pregnancy and breastfeeding
  • Diabetic retinopathy (GH may worsen)
Regulatory (US)Not FDA-approved. Research chemical only.Not FDA-approved. Development discontinued. Research chemical only.

Research Material Specifications

Catalog specifications for the corresponding research materials, including batch documentation coverage.

SpecificationGHRP-6Hexarelin
Purity Standard≥98%≥98%
CAS Number87616-84-0140703-51-1
Molecular FormulaN/AN/A
Available Formats10mg5mg
Batch COAs Published
Stock StatusOut of stockOut of stock

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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