All Comparisons
Cortagen vs PE-22-28
Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.
Cortagen: DPE-22-28: D
| Attribute | Cortagen | PE-22-28 |
|---|---|---|
| Category | Nootropic / Neuroprotective | Nootropic / Neuroprotective |
| Evidence Rating | D — Preclinical / Uncontrolled Russian Studies | D — Preclinical Only |
| Clinical Status | Preclinical / small open-label Russian studies only. No controlled clinical trials. Available as a dietary supplement in Russia. | Preclinical tool compound only. No clinical trials. No regulatory evaluation. |
| Mechanism | Cortagen is proposed by the Khavinson group to penetrate cells and interact with DNA regulatory sequences to normalize gene expression in cortical neurons. Preclinical studies from the developer report that cortagen promotes neuronal survival under ischemic and neurotoxic conditions, modulates neuro... | PE-22-28 blocks the TREK-1 two-pore-domain potassium channel (KCNK2/K2P2.1), which is widely expressed in the brain. TREK-1 knockout mice display a depression-resistant phenotype, suggesting that TREK-1 blockade may have antidepressant effects. PE-22-28 is a more potent and shorter analog of spadin ... |
| Half-Life | — | Improved over spadin in rodent work; not established in humans |
| Bioavailability | — | — |
| Molecular Weight | ~446 g/mol | ~800 to 900 g/mol |
| WADA Status | Not Listed | Not Listed |
| Research Half-Life | — | Improved over spadin in rodent work; not established in humans |
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| Regulatory (US) | Not FDA-approved or evaluated. Occasionally sold online as a research peptide. | Not FDA-evaluated. Research tool compound. Sold by some peptide suppliers as a research chemical. |
Research Material Specifications
Catalog specifications for the corresponding research materials, including batch documentation coverage.
| Specification | Cortagen | PE-22-28 |
|---|---|---|
| Purity Standard | >99% | >99% |
| CAS Number | — | — |
| Molecular Formula | — | — |
| Available Formats | 20mg | 10mg |
| Batch COAs Published | — | — |
| Stock Status | Out of stock | Out of stock |
Availability at Volta Peptides
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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