receptor pharmacology

Hexarelin: Structure, GHS-R1a and CD36 Binding, and Receptor Desensitisation

Hexarelin is a synthetic hexapeptide derived from GHRP-6 and an agonist at the ghrelin receptor GHS-R1a. It also binds a second, unrelated site, CD36, identified in 2002 by photoaffinity labelling. Its structure, both binding sites, and the receptor internalisation behind its tachyphylaxis.