Peptides for Research Only

2 research peptides are currently studied for research only. This guide ranks them by evidence strength and covers their mechanisms, safety profiles, and current clinical status.

Evidence Rating: D

Category: Growth Factor

IGF-1 DES (Des(1-3)IGF-1) is a truncated form of insulin-like growth factor 1, missing the first three N-terminal amino acids (Gly-Pro-Glu). This modification dramatically reduces binding to IGF binding proteins (IGFBPs), resulting in approximately 10-fold greater potency than native IGF-1 at the IGF-1 receptor in certain tissue contexts. It occurs naturally in the brain as a product of post-translational processing. It is used exclusively in research and is banned by WADA. No clinical trials have been conducted.

Key claims: More potent than native IGF-1 for cell proliferation; Promotes muscle growth.

Evidence Rating: D

Category: Growth Hormone Fragment

HGH Fragment 176-191 is a synthetic peptide corresponding to the C-terminal portion (amino acids 176-191) of human growth hormone. This 16-amino acid fragment was identified as the region of GH responsible for its lipolytic (fat-burning) activity. A stabilized analog, AOD-9604, reached Phase III clinical trials but failed to demonstrate sufficient efficacy for obesity. WADA bans this peptide.

Key claims: Promotes fat loss without GH side effects; Does not affect blood glucose or insulin.