Peptides for Migraine Research

2 research peptides are currently studied for migraine research. This guide ranks them by evidence strength and covers their mechanisms, safety profiles, and current clinical status.

Evidence Rating: A

Category: Pain / Migraine

Calcitonin Gene-Related Peptide (CGRP) is a 37-amino-acid neuropeptide and one of the most potent vasodilators known. CGRP itself is endogenous and released by trigeminal sensory neurons during migraine attacks. The therapeutic strategy is to block CGRP or its receptor, not to administer it. This makes CGRP unique among peptides on this platform — the clinical interest is in its antagonism..

Key claims: Central role in migraine pathophysiology; Anti-CGRP antibodies prevent migraine.

Evidence Rating: D

Category: Neuropeptide / Reference

PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) is a neuropeptide that exists in two biologically active forms: PACAP-38 (38 amino acids, MW ~4534.3 g/mol) and PACAP-27 (27 amino acids, the N-terminal fragment). PACAP-38 is the predominant form in the brain. It belongs to the VIP/secretin/glucagon superfamily and shares 68% sequence homology with VIP. PACAP is a potent neuroprotective, neurotrophic, and immunomodulatory peptide with emerging roles in migraine pathophysiology, PTSD, and neurodegenerative diseases.

Key claims: Triggers migraine attacks; Potent neuroprotective agent.