Peptides for IBS with Constipation
Comprehensive guide to 2 peptides researched for ibs with constipation, ranked by evidence strength from FDA-approved to early preclinical. Each compound is evaluated on mechanism, clinical status, and safety profile.
Overview
2 research peptides are currently studied for ibs with constipation. This guide ranks them by evidence strength and covers their mechanisms, safety profiles, and current clinical status.
Plecanatide — FDA Approved
Evidence Rating: A
Category: Gastrointestinal / GC-C Agonist
Plecanatide is a 16-amino-acid synthetic peptide (MW ~1681.9 g/mol) that is a structural analog of uroguanylin, an endogenous intestinal peptide. Plecanatide acts locally in the intestinal lumen with minimal systemic absorption, functioning as a guanylate cyclase-C (GC-C) agonist to increase intestinal fluid secretion.
Key claims: Increases complete spontaneous bowel movements in chronic constipation; Reduces abdominal pain in IBS-C.
Linaclotide — FDA Approved
Evidence Rating: A
Category: Gastrointestinal / GC-C Agonist
Linaclotide is a 14-amino-acid synthetic peptide (MW ~1526.8 g/mol) structurally related to the endogenous guanylin and uroguanylin peptides, containing three intramolecular disulfide bonds. Linaclotide is a guanylate cyclase-C (GC-C) agonist that acts locally in the intestinal lumen with minimal systemic absorption, increasing intestinal fluid secretion and reducing visceral pain signaling.
Key claims: Improves bowel function and reduces abdominal pain in IBS-C; Increases complete spontaneous bowel movements in CIC.
Shop Research Peptides
BPC-157 5mg
5mg
Retatrutide 20mg
20mg
Retatrutide 10mg
10mg
GHK-Cu 50mg
50mg
Tesamorelin 10mg
10mg
BPC-157 10mg
10mg
Tirzepatide 10mg
10mg
KPV 10mg
10mg
Quality Documentation
Review batch documentation before making research purchasing decisions. Volta pairs product education with COA literacy so researchers can evaluate purity, identity, lot details, and testing context.
Product cards on this page link to current catalog entries and available quality documentation.
Peptide Tools
Follow Research Updates
Get new research pages, product updates, tool releases, and quality resources from Volta.
Subscribe