Neurotrophic Research Peptides
4 peptides with demonstrated neurotrophic effects in research. Sorted by evidence quality from strongest to exploratory.
Overview
4 research peptides demonstrate neurotrophic properties. This collection covers their mechanisms, evidence base, and research applications.
Semax
Preclinical | Nootropic / Neuroprotective
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from adrenocorticotropic hormone (ACTH) fragment 4-10, with an added Pro-Gly-Pro sequence for metabolic stability. Molecular weight is approximately 813.
Mechanism: Semax is a brain-selective heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro, MW ~813.88 g/mol) that crosses the blood-brain barrier via intranasal absorption.
Dihexa
No Regulatory Activity | Nootropic / Cognitive
Dihexa (PNB-0408) is a synthetic small molecule derived from angiotensin IV, developed at Washington State University by the Harding lab.
Mechanism: Dihexa activates the hepatocyte growth factor receptor (c-Met) by binding to HGF molecules and dimerizing with endogenous HGF to form a functional ligand, producing more physiological signaling than...
Cerebrolysin
Phase I–II Clinical Trials | Nootropic / Neuroprotective
Cerebrolysin is a brain-derived peptide complex consisting of low-molecular-weight neuropeptides (25%) and free amino acids (75%), produced by enzymatic hydrolysis of purified porcine brain proteins.
Mechanism: Cerebrolysin provides multimodal neuroprotection through several pathways: it enhances neurogenesis and neuroplasticity via activation of PI3K/AKT and Sonic Hedgehog (Shh) signaling, promotes...
P21
Preclinical | Nootropic / Neurogenesis
P21 is a synthetic peptide derived from the active region of Ciliary Neurotrophic Factor (CNTF) that promotes hippocampal neurogenesis without the immunogenic side effects of full-length CNTF.
Mechanism: P21 is a modified tetrapeptide (Ac-DGGL-OH) linked to adamantane to enhance blood-brain barrier penetration.
Shop Research Peptides
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Retatrutide 10mg
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Sermorelin 5mg
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Tesamorelin 10mg
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Quality Documentation
Review batch documentation before making research purchasing decisions. Volta pairs product education with COA literacy so researchers can evaluate purity, identity, lot details, and testing context.
Product cards on this page link to current catalog entries and available quality documentation.
Related Research News
FDA Panel Recommends Semax for Pharmacy Compounding: Manufacturing News
An FDA advisory panel has recommended the peptide Semax be added to the pharmacy compounding list, a move that could expand access for researchers. The decision comes amid broader discussions about peptide regulation, including a vote against emideltide. This semax manufacturing news highlights shifting industry dynamics.
Dihexa Research Review: Mechanism, Preclinical Evidence, Safety Questions, and Retractions
Dihexa (PNB-0408) research review: proposed HGF/c-Met mechanism, preclinical findings, 2025 retraction, notice of concern, safety, and evidence quality assessment.
Semax Research: Mechanisms of Neuroprotection, Memory, and Vascular Recovery in Preclinical Models
Explore research on Semax: memory, neuroprotection, cerebral ischemia, gene expression, and calcium homeostasis in preclinical studies.
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