Metabolic / Mitochondrial Research Peptides Guide
In-depth research guide covering 3 peptides in the Metabolic / Mitochondrial category. Includes evidence ratings, mechanisms, and clinical status for each compound.
Overview
This guide covers 3 research peptides in the Metabolic / Mitochondrial category. Each compound is evaluated on its evidence base, mechanism, safety profile, and current clinical status.
MOTS-c — Preclinical
Evidence: D | Status: Research-only / No human clinical trials completed (Phase 1 of analog CB4211 only)
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene (MT-RNR1). Discovered in 2015 by Lee et al.
Use cases: Metabolic Health, Anti-Aging
SS-31 — FDA Approved
Evidence: A | Status: FDA-approved (Forzinity, September 2025) for Barth syndrome. Phase II (heart failure, renal dysfunction, age-related macular degeneration).
SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane, binding to cardiolipin and stabilizing cristae structure.
Use cases: Anti-Aging, Metabolic Health
Humanin — Preclinical
Evidence: D | Status: Preclinical. No completed clinical trials. Epidemiological studies show correlation with longevity.
Humanin is a 21-24 amino acid mitochondria-derived peptide (MDP) encoded by the MT-RNR2 gene in mitochondrial DNA. It was originally discovered in 2001 for its ability to protect neurons from Alzheimer's disease-related toxicity.
Use cases: Anti-Aging, Cognitive Enhancement
Shop Research Peptides
MOTS-C 20mg
20mg
Retatrutide 20mg
20mg
BPC-157 5mg
5mg
Ipamorelin 10mg
10mg
Semaglutide 10mg
10mg
TB-500 5mg
5mg
Retatrutide 10mg
10mg
GHK-Cu 50mg
50mg
Sermorelin 5mg
5mg
Quality Documentation
Review batch documentation before making research purchasing decisions. Volta pairs product education with COA literacy so researchers can evaluate purity, identity, lot details, and testing context.
Product cards on this page link to current catalog entries and available quality documentation.
Related Research News
MOTS-C and Metabolism: How Does MOTS-C Improve Endurance and Bone Strength?
Explore the preclinical science behind MOTS-C, a mitochondrial peptide investigated for its effects on metabolism, endurance, and bone strength.
SS-31 (Elamipretide): A Research Review on ALS, Diaphragm Strength, and Mitochondrial Function
SS-31 (Elamipretide) research for ALS, diaphragm strength, and mitochondrial function. Preclinical evidence review.
Humanin: Mitochondrial-Derived Peptide for Cytoprotection and Longevity Research
Explore Humanin, a mitochondrial-derived peptide investigated for cytoprotection, anti-apoptosis, and longevity mechanisms in preclinical research.
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