Metabolic / Mitochondrial Research Peptides Guide
Overview
This guide covers 3 research peptides in the Metabolic / Mitochondrial category. Each compound is evaluated on its evidence base, mechanism, safety profile, and current clinical status.
MOTS-c — Preclinical
Evidence: D | Status: Research-only / No human clinical trials completed (Phase 1 of analog CB4211 only)
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene (MT-RNR1). Discovered in 2015 by Lee et al.
Use cases: Metabolic Health, Anti-Aging
SS-31 — FDA Approved
Evidence: A | Status: FDA-approved (Forzinity, September 2025) for Barth syndrome. Phase II (heart failure, renal dysfunction, age-related macular degeneration).
SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane, binding to cardiolipin and stabilizing cristae structure.
Use cases: Anti-Aging, Metabolic Health
Humanin — Preclinical
Evidence: D | Status: Preclinical. No completed clinical trials. Epidemiological studies show correlation with longevity.
Humanin is a 21-24 amino acid mitochondria-derived peptide (MDP) encoded by the MT-RNR2 gene in mitochondrial DNA. It was originally discovered in 2001 for its ability to protect neurons from Alzheimer's disease-related toxicity.
Use cases: Anti-Aging, Cognitive Enhancement
Related Products
MOTS-C 20mg
20mg
Related Research News
MOTS-c Guide: Mitochondrial Peptide for Canada Research
MOTS-c stands out as a 16-amino-acid peptide encoded by mitochondrial DNA, distinct from nuclear-gene peptides. Discovered in 2015, it influences metabolic regulation, AMPK signaling, and aging mechanisms. This guide details its features, verification steps, and research applications for Canadian buyers.
MOTS-c: The Mitochondrial Peptide for Metabolic Health
MOTS-c, a 16-amino-acid peptide encoded by mitochondrial DNA, regulates metabolism and responds to stress by signaling from mitochondria to the nucleus. Research shows it activates AMPK, declines with age, and mimics exercise effects in preclinical models. Studies link lower levels to type 2 diabetes and age-related physical decline.
Anti-Aging Peptides: Research Compounds for Metabolism, Muscle, and Tissue Health
Explore a curated selection of anti-aging research peptides including BPC-157, GHK-CU, KPV, MOTS-C, NAD+, Retatrutide, SS-31, TB-500, and others. These compounds are studied for their potential roles in metabolism support, muscle growth, weight loss, and skin, tissue, and bone health. Average purity across products is 99.77%.